PMID: 9194143May 1, 1997Paper

Side effects of low dose neuroleptics and their impact on clinical outcome in generalized anxiety disorder

Progress in Neuro-psychopharmacology & Biological Psychiatry
C WurthmannE Lehmann

Abstract

1. The present study was designed to determine the impact of neuroleptic side effects on clinical outcome in generalized anxiety disorder. 2. 205 outpatients entered the study. In an open label design fluspirilene 1.5 mg per week was administered for a period of 6 weeks. 3. Consistent with previous studies fluspirilene demonstrated again anxiolytic properties and was in general tolerated well. 4. However, in responders significantly less side effects were observed than in nonresponders. The interaction between tolerability and clinical outcome is the main finding of the present study. 5. In conclusion, the data suggest, that neuroleptic treatment of generalized anxiety disorder should be guided by paying more attention to potential side effects. If under neuroleptic treatment of generalized anxiety disorders side effects are observed, pharmacotherapy should be discontinued, because this fact predicts an unfavourable clinical outcome.

References

Mar 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·K Heinrich, E Lehmann
Nov 1, 1990·Pharmacopsychiatry·J TegelerK Heinrich
Sep 1, 1987·Journal of Affective Disorders·R J KahnL M Frankenthaler
Apr 1, 1993·Journal of Consulting and Clinical Psychology·D L Chambless, M M Gillis
Oct 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·C WurthmannU Pester

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Citations

Oct 3, 1999·Journal of Neurosurgery·R D LindenC B Shields
Dec 6, 2000·Journal of Clinical Psychopharmacology·E WeissW W Fleischhacker
Mar 9, 2017·Harvard Review of Psychiatry·Rafael Ferreira-GarciaRafael Christophe Freire
Sep 28, 2004·CNS Spectrums·Moira A Rynn, Olga Brawman-Mintzer

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