PMID: 1190419Sep 1, 1975Paper

[Side effects of nitrous oxide (author's transl)].

Der Anaesthesist
F T Schuh

Abstract

When nitrous oxide is breathed the alvolar partial pressure will cause it to diffuse into the blood, tissues and gas-containing spaces within the body until equilibrium is reached. At the same time nitrogen will be excreted from tissues and blood to alveolar gas. There is a 35 fold difference in the blood-gas partition coefficient between nitrous oxide (0.47) and nitrogen (0.013). For every molecule of nitrogen that is removed from the aircontaining space in the body, 35 molecules of nitrous oxide are transferred from the blood to the air space. This differential solubility of nitrogen and nitrous oxide results either in an increase in the volume of the gas space if the space is compliant (gastrointestinal tract, pneumothorax, air embolus, cuff of the endotracheal tube), or in an increase in the pressure if the space is non-compliant (pneumencephalography, middle ear, sinus). The clinical significance of these side effects of nitrous oxide and experimental studies are discussed.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Medical Toxicology
J B Brodsky, E N Cohen
Injury
Martin Hamilton-Farrell, Abir Bhattacharyya
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Hua-feng LiJin Liu
© 2022 Meta ULC. All rights reserved