Side effects of sirolimus

Transplantation Proceedings
S MerkelA Schwarz

Abstract

The mTOR inhibitor sirolimus improves renal transplant function compared with the nephrotoxic calcineurin inhibitors. We evaluated retrospectively the adverse events in 119 of 134 patients getting sirolimus which seemed to be caused by sirolimus. Patients were converted to sirolimus because of malignancies (n = 47), a creeping creatinine (n = 33), or hypertension (n = 26). One cohort had started sirolimus from the time of transplantation (n = 28). A rise in serum lipids and a decrease in hemoglobin were seen relatively regularly, while arthralgia, peripheral edema, gastrointestinal complaints, skin disorders, electrolyte disturbances, and infections occurred only occasionally. Interestingly, 31% of patients developed doubling or more proteinuria. Among renal biopsies, 9/13 showed a glomerulopathy which in 6 cases was de novo and in 3 cases, a presumed recurrence of the primary kidney disease. Thus, we think that caution is required, particularly in connection with preexisting glomerular disease.

References

Feb 24, 2004·Journal of the American Society of Nephrology : JASN·Henri KreisUNKNOWN Rapamune Maintenance Regimen Trial
Apr 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fernando C FervenzaUNKNOWN Mayo Nephrology Collaborative Committee
May 19, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alfredo MotaUNKNOWN Rapamune Maintenance Regimen Trial
Feb 5, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Dirk R J Kuypers
May 25, 2005·Pediatric Transplantation·Rakesh SindhiRaman Venkataramanan
Jun 30, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Viorica BumbeaLionel Rostaing

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Citations

Jul 16, 2011·International Urology and Nephrology·Tainá Veras de Sandes FreitasJosé Osmar Medina-Pestana
Nov 5, 2008·Journal of Periodontology·Luís Otávio Miranda CotaFernando Oliveira Costa
Apr 25, 2009·Expert Opinion on Investigational Drugs·Mark Rami Barakat, P K Kaiser
Feb 5, 2013·Transplantation Proceedings·K FidanO Söylemezoğlu
Apr 26, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·B Hartmann
Nov 1, 2007·Nitric Oxide : Biology and Chemistry·You-Lin TainChris Baylis
Dec 5, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Adrian LiewAnantharaman Vathsala
Oct 19, 2011·Pediatric Transplantation·Belde Kasap
Dec 17, 2008·Pediatric Transplantation·Nauzer ForbesGuido Filler
Oct 25, 2016·Ophthalmology·Quan Dong NguyenUNKNOWN Sirolimus study Assessing double-masKed Uveitis tReAtment (SAKURA) Study Group
Dec 21, 2017·Expert Opinion on Drug Delivery·Hanan Al-LawatiAfsaneh Lavasanifar
Oct 3, 2018·The Journal of Rheumatology·Desmond Y H YapTak Mao Chan
Nov 6, 2018·Clinical Pharmacology and Therapeutics·Ram R Miller, Ronenn Roubenoff
Feb 16, 2008·Current Opinion in Nephrology and Hypertension·Behzad Najafian, Bertram L Kasiske
Oct 4, 2016·The Journal of Clinical Endocrinology and Metabolism·Marie SzymanowskiJean-Baptiste Arnoux
Jun 15, 2021·Expert Opinion on Drug Metabolism & Toxicology·Kathleen M JobCatherine M Sherwin

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