Side of motor onset is associated with hemisphere-specific memory decline and lateralized gray matter loss in Parkinson's disease

Parkinsonism & Related Disorders
Eun-Young LeeXuemei Huang

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder that generally begins with asymmetric motor symptoms that persist over time. This suggests that the dysfunction in the nigrostriatal motor circuit may be lateralized. The present study examined whether the asymmetric motor presentation is associated with hemisphere-specific cognitive decline and lateralized gray matter volume loss. Data from comprehensive cognitive tests that measured visuospatial and verbal functions and high-resolution T1-weighted magnetic resonance images of the brain were acquired in 23 PD subjects with left-side motor symptom onset (PDL), 23 PD subjects with right-side onset (PDR), and 23 matched Controls. GM volume differences were assessed using voxel-based morphometry (VBM). Cognitive results and VBM were compared among the three groups, and correlation analyses were performed between those cognitive domains and brain areas that showed significant differences. PDL subjects had lower performance on visuospatial memory tasks compared to PDR. Furthermore, PDL subjects experienced lateralized GM loss, which was localized predominantly in the right hemisphere contralateral to the side of motor symptom onset. Visuospatial memory performance in PDL was c...Continue Reading

References

Jan 1, 1992·Movement Disorders : Official Journal of the Movement Disorder Society·J W LangstonR Watts
Dec 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·P K MorrishD J Brooks
Mar 17, 2000·Brain Research. Brain Research Reviews·F A Middleton, P L Strick
Jan 9, 2003·Trends in Cognitive Sciences·Kai Vogeley, Gereon R. Fink
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Feb 19, 2009·Trends in Cognitive Sciences·Angela D Friederici
Oct 14, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Anouk van der HoornBauke M de Jong
Nov 18, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Michel Thiebaut de SchottenMarco Catani
Dec 12, 2012·Journal of Clinical and Experimental Neuropsychology·Michele PolettiUbaldo Bonuccelli

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Citations

Jan 19, 2016·Neuropsychologia·P Garrido-VásquezS A Kotz
Jul 5, 2016·Neuroscience and Biobehavioral Reviews·Tetsuya AsakawaYing Xia
Sep 28, 2016·Frontiers in Neurology·Maria C A SantosAnelyssa D'Abreu
Mar 8, 2017·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Stuti L MisraCharles N J McGhee
Sep 1, 2017·Human Brain Mapping·Lora MinkovaStefan Klöppel
Apr 25, 2020·The International Journal of Neuroscience·Ersin Kasım Ulusoy, Döndü Melek Ulusoy
Apr 13, 2018·Frontiers in Aging Neuroscience·Dongfang ShenYujun Pan
Apr 16, 2018·Cell and Tissue Research·P RiedererR Krüger
Dec 24, 2018·Aging Cell·Madalena EstevesHugo Leite-Almeida
Apr 11, 2018·Frontiers in Human Neuroscience·Xiaojun XuMinming Zhang
Nov 18, 2020·Journal of Clinical and Experimental Neuropsychology·Filip HavlíkOndrej Bezdicek
Apr 13, 2021·Applied Neuropsychology. Adult·Marilyn J SteinbachDavid W Harrison

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