Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic

Cancer Research
Lubna PatrawalaDean G Tang

Abstract

Recently, several human cancers including leukemia and breast and brain tumors were found to contain stem-like cancer cells called cancer stem cells (CSC). Most of these CSCs were identified using markers that identify putative normal stem cells. In some cases, stem-like cancer cells were identified using the flow cytometry-based side population technique. In this study, we first show that approximately 30% of cultured human cancer cells and xenograft tumors examined ( approximately 30 in total) possess a detectable side population. Purified side population cells from two cell lines (U373 glioma and MCF7 breast cancer) and a xenograft prostate tumor (LAPC-9) are more tumorigenic than the corresponding non-side population cells. These side population cells also possess some intrinsic stem cell properties as they generate non-side population cells in vivo, can be further transplanted, and preferentially express some "stemness" genes, including Notch-1 and beta-catenin. Because the side population phenotype is mainly mediated by ABCG2, an ATP-binding cassette half-transporter associated with multidrug resistance, we subsequently studied ABCG2+ and ABCG2- cancer cells with respect to their tumorigenicity in vivo. Although side popu...Continue Reading

References

Nov 2, 2001·Nature·T ReyaI L Weissman
Apr 24, 2002·Developmental Biology·Bryan E WelmMargaret A Goodell
Sep 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sheng ZhouBrian P Sorrentino
Oct 16, 2002·The Journal of Cell Biology·Atsushi AsakuraMichael A Rudnicki
Mar 11, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ross SummerAlan Fine
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
May 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi KubotaRalph L Brinster
Jul 25, 2003·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Rupesh I BhattNoel W Clarke
Aug 12, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Adam GiangrecoBarry R Stripp
Sep 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Emmanuelle PasseguéIrving L Weissman
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Martin Raff
Dec 3, 2003·Blood·Daniel J PearceDominique Bonnet
Dec 3, 2003·Proceedings of the National Academy of Sciences of the United States of America·Houman D HemmatiHarley I Kornblum
Dec 13, 2003·Science·Tudorita TumbarElaine Fuchs
Dec 17, 2003·Journal of Neurochemistry·Jingli CaiKatsutoshi Furukawa
Dec 23, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ilaria FalciatoriElena Vicini
Jan 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Toru KondoTetsuya Taga
Mar 10, 2004·Cell·Amy J Wagers, Irving L Weissman
Mar 24, 2004·Cell·Elaine FuchsGeraldine Guasch
Mar 30, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ross SummerAlan Fine
Mar 31, 2004·Experimental Cell Research·Charlotte TrielUffe Birk Jensen
Jun 24, 2004·Experimental Cell Research·Helen ClaytonMaria dM Vivanco
Jul 10, 2004·Experimental Cell Research·Federica MontanaroLouis M Kunkel
Sep 21, 2004·Oncogene·Ian Chambers, Austin Smith
Sep 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·C Hirschmann-JaxM K Brenner
Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks

❮ Previous
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Citations

Feb 4, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Costas G Hadjipanayis, Erwin G Van Meir
Jun 8, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Kuan-Hsuan ChenYi-Wei Chen
May 8, 2009·Langenbeck's Archives of Surgery·Ivan IschenkoChristiane J Bruns
Nov 7, 2008·Brain Tumor Pathology·Takuichiro HideToru Kondo
Mar 8, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yang JiangXiao-Ming Jin
Oct 30, 2007·Breast Cancer Research and Treatment·Jiangbing ZhouYing Zhang
Aug 11, 2012·Breast Cancer Research and Treatment·Rabia A GilaniAngela H Brodie
Feb 27, 2007·Cancer Metastasis Reviews·Robert W RobeySusan E Bates
Dec 17, 2009·Cancer Metastasis Reviews·William D BrandtDavid M Berman
Sep 11, 2008·Cellular and Molecular Neurobiology·Xing-gang MaoHai-ning Zhen
Feb 26, 2009·Journal of Mammary Gland Biology and Neoplasia·David C Harmes, James DiRenzo
Feb 17, 2006·Current Urology Reports·Peter S Nelson, Bruce Montgomery
Nov 19, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Adam Yagui-BeltránDavid M Jablons
Mar 26, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jun Dou, Ning Gu
Jan 30, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mu-mu ShiEn-Hua Wang
Jun 29, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dan YuCaigang Liu
Mar 19, 2013·The International Journal of Biochemistry & Cell Biology·Jun MaoLianhong Li
Apr 27, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Xiao-qin ZhaoLi-Wu Fu
Feb 24, 2012·Cell Research·Dean G Tang
Jan 19, 2008·Nature·Tobias SchattonMarkus H Frank
Apr 24, 2008·Nature Clinical Practice. Oncology·Andreas Trumpp, Otmar D Wiestler
Mar 8, 2006·Nature Medicine·Kornelia Polyak, William C Hahn
Sep 14, 2007·Nature Reviews. Cancer·John Stingl, Carlos Caldas
Sep 12, 2008·Nature Reviews. Cancer·Jane E Visvader, Geoffrey J Lindeman
Oct 2, 2009·Nature Reviews. Drug Discovery·Bin-Bing S ZhouPeter B Dirks
Jun 19, 2013·Oncogene·X WangD S Conklin
Dec 17, 2005·Leukemia·M V Blagosklonny
Nov 7, 2007·Prostate Cancer and Prostatic Diseases·J Miki, J S Rhim
Nov 15, 2007·Stem Cells and Development·Mi-Kyung Kang, Soo-Kyung Kang
Apr 2, 2013·Stem Cells and Development·Jiang-Jie DuanShi-Cang Yu

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