Sidman instrumental avoidance initially depends on lateral and basal amygdala and is constrained by central amygdala-mediated Pavlovian processes.

Biological Psychiatry
Gabriel Lázaro-MuñozChristopher K Cain

Abstract

The lateral (LA) and central (CE), but not basal (B), amygdala nuclei are necessary for reactive Pavlovian fear responses such as freezing. The amygdala also plays a key role in the acquisition and expression of active instrumental defensive behaviors, but little is known about the specific roles of amygdala nuclei. Using a Sidman active avoidance (AA) task, we examined the necessity of LA, B, and CE for learning and performance. Pavlovian freezing was simultaneously assessed to examine the contributions of amygdala nuclei to the transition from reactive to active defensive responding. Rats received electrolytic lesions of LA, CE, or B before AA training, or following overtraining. Rats that expressed low levels of AA performance during training received bilateral electrolytic lesions to CE to eliminate competing freezing reactions and rescue AA. AA performance and freezing were assessed. Damage to LA and B, but not CE, impaired the acquisition of AA. Performance of AA became amygdala-independent following overtraining. CE lesions abolished Pavlovian freezing and rescued instrumental AA performance in rats that expressed low levels of avoidance responses and high levels of freezing during training. Although the acquisition of P...Continue Reading

References

Jul 1, 1979·Behavior Genetics·F R BrushP C Sakellaris
Feb 1, 1975·Journal of Comparative and Physiological Psychology·S P GrossmanL Walsh
Jan 1, 1972·Journal of Comparative and Physiological Psychology·H Anisman, T G Waller
Nov 1, 1972·Journal of Comparative and Physiological Psychology·D C Blanchard, R J Blanchard
Apr 1, 1970·Journal of Comparative and Physiological Psychology·R J BlanchardR A Fial
Mar 1, 1969·Journal of Comparative and Physiological Psychology·R J Blanchard, D C Blanchard
Feb 1, 1967·Journal of Comparative and Physiological Psychology·J B Overmier, M E Seligman
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Dec 1, 2001·The American Journal of Psychiatry·J E LeDoux, J M Gorman
Jan 22, 2002·Neuroscience and Biobehavioral Reviews·K A Keay, R Bandler
Aug 1, 1953·Journal of Comparative and Physiological Psychology·M SIDMAN
Feb 1, 1964·Experimental Neurology·E E KRIECKHAUSJ KENYON
Aug 1, 1964·Psychological Bulletin·G V GODDARD
Apr 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Greg D GaleMichael S Fanselow
Jun 24, 2004·Journal of Neurophysiology·Denis ParéJoseph E Ledoux
Apr 30, 2005·Science·Robert M Sapolsky
Aug 16, 2005·Journal of Chemical Neuroanatomy·Ken W S Ashwell, George Paxinos
Oct 21, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David Anglada-Figueroa, Gregory J Quirk
Mar 21, 2006·Trends in Neurosciences·Bernard W Balleine, Simon Killcross
May 3, 2006·Journal of Consulting and Clinical Psychology·K Chase Stovall-McClough, Marylene Cloitre
Aug 8, 2006·Annals of the New York Academy of Sciences·Bessel A van der Kolk
Sep 5, 2006·Journal of Anxiety Disorders·Ansgar Conrad, Walton T Roth
Dec 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ann E WilenskyJoseph E LeDoux
May 17, 2007·The Journal of General Psychology·Beatrice M de OcaMichael S Fanselow
Jun 27, 2007·Statistics in Medicine·Roderick J LittleSiobán D Harlow
Oct 11, 2007·Journal of Experimental Psychology. Animal Behavior Processes·Christopher K Cain, Joseph E LeDoux
May 27, 2008·Behavioural Brain Research·R J ServatiusT R Minor
Apr 30, 2009·Annual Review of Neuroscience·Sarina M RodriguesRobert M Sapolsky
May 27, 2009·Nature Reviews. Neuroscience·Benno RoozendaalSumantra Chattarji
Jul 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Andrew M PoulosMichael S Fanselow

❮ Previous
Next ❯

Citations

May 24, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vanda FariaTomas Furmark
Sep 6, 2012·Neuropsychobiology·Carlos M ContrerasRemedios Mendoza-López
Mar 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Justin M Moscarello, Joseph E LeDoux
Feb 15, 2014·Experimental Brain Research·Donald F SiwekSubimal Datta
Jul 28, 2012·Expert Opinion on Investigational Drugs·Christopher K CainJohn H Kehne
Nov 6, 2015·Cognition·Francesco RigoliRaymond J Dolan
Sep 6, 2015·Neuroscience and Biobehavioral Reviews·Kate M Wassum, Alicia Izquierdo
Apr 11, 2012·The European Journal of Neuroscience·Michael A McDannaldGeoffrey Schoenbaum
Oct 15, 2013·Hippocampus·María E Garín-AguilarRoberto A Prado-Alcalá
Jun 9, 2010·Biological Psychiatry·Kerry J Ressler
Oct 7, 2015·Frontiers in Behavioral Neuroscience·Caio MaximinoAnderson Manoel Herculano
Mar 1, 2012·Neuron·Joseph LeDoux
Mar 27, 2012·Neuron·Kelly R TanChristian Lüscher
Oct 8, 2013·Behavioural Brain Research·Michael W SchlundSimon Dymond
Nov 12, 2014·Frontiers in Behavioral Neuroscience·Anton IlangoFrank W Ohl
Oct 4, 2014·Frontiers in Behavioral Neuroscience·Margaret G McCueChristopher K Cain
May 23, 2014·Frontiers in Behavioral Neuroscience·Vincent D CampeseChristopher K Cain
Sep 9, 2016·Frontiers in Behavioral Neuroscience·Caroline C de OliveiraRaquel C R Martinez
Oct 30, 2016·Behavioural Brain Research·Mihee SongJune-Seek Choi
Mar 30, 2018·Nature Reviews. Neuroscience·Joseph LeDoux, Nathaniel D Daw
Apr 27, 2016·Cerebral Cortex·Yosuke SagaLéon Tremblay
Jul 29, 2018·Nature Reviews. Neuroscience·Robert J FensterJunghyup Suh
Apr 24, 2019·Stress : the International Journal on the Biology of Stress·Rimenez R SouzaChrista K McIntyre
Apr 14, 2020·Journal of Neuroscience Research·Matthew A GeramitaSusanne E Ahmari
Nov 19, 2015·Frontiers in Behavioral Neuroscience·Vincent D CampeseJoseph E LeDoux
Sep 28, 2018·Psychopharmacology·Freddyson J Martínez-RiveraGregory J Quirk
Jun 17, 2020·Learning & Memory·Lindsay C LaughlinChristopher K Cain
Oct 11, 2017·Frontiers in Behavioral Neuroscience·Vincent D CampeseJoseph E LeDoux
Oct 10, 2020·Neuroscience and Biobehavioral Reviews·Elizabeth E ManningMihaela D Iordanova
Oct 17, 2020·Learning & Memory·Vinn D CampeseJoseph E LeDoux
Feb 18, 2021·Learning & Memory·Thomas LapointeFrancesco Leri
Jul 1, 2020·Behavioural Brain Research·Atsuhito YamagishiNobuya Sato
Mar 12, 2021·Journal of Neurochemistry·Patrick T PiantadosiAndrew Holmes
Apr 20, 2021·Frontiers in Neuroscience·James J A LivermoreKarin Roelofs
May 21, 2021·Neurobiology of Learning and Memory·Cecily R OleksiakJustin M Moscarello

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.