Sidney Farber and the treatment of childhood acute lymphoblastic leukemia with a chemotherapeutic agent

Pediatric Hematology and Oncology
Domenico Ribatti

Abstract

Acute lymphoblastic leukemia (ALL) is the most common malignancy affecting children accounting for approximately 30% of childhood cancers, which was uniformly fatal before the advent of effective chemotherapy. In this historical note, the fundamental contribution of Sidney Farber to the treatment of ALL by using, for the first time, aminopterin-a chemotherapeutic agent-has been recognized.

References

Dec 1, 1972·Cancer·J F Holland, O Glidewell
Jan 1, 1983·Critical Reviews in Oncology/hematology·L P Miller, D R Miller
Aug 27, 1998·The New England Journal of Medicine·C H Pui, W E Evans

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Citations

Feb 1, 2014·Pediatric Blood & Cancer·Brigitta U Mueller
Aug 12, 2014·Clinical and Translational Science·Naveen AshishAmy Taylor
Apr 3, 2013·Molecular and Cellular Biology·Marie-Josée FournierRachid Mazroui
Apr 15, 2020·Cancers·Abdulaziz B Hamid, Ruben C Petreaca

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