Siemens Immulite Aspergillus-specific IgG assay for chronic pulmonary aspergillosis diagnosis

Medical Mycology
Iain D PageDavid W Denning

Abstract

Chronic pulmonary aspergillosis (CPA) complicates underlying lung disease, including treated tuberculosis. Measurement of Aspergillus-specific immunoglobulin G (IgG) is a key diagnostic step. Cutoffs have been proposed based on receiver operating characteristic (ROC) curve analyses comparing CPA cases to healthy controls, but performance in at-risk populations with underlying lung disease is unclear. We evaluated optimal cutoffs for the Siemens Immulite Aspergillus-specific IgG assay for CPA diagnosis in relation to large groups of healthy and diseased controls with treated pulmonary tuberculosis. Sera from 241 patients with CPA attending the UK National Aspergillosis Centre, 299 Ugandan blood donors (healthy controls), and 398 Ugandans with treated pulmonary tuberculosis (diseased controls) were tested. Radiological screening removed potential CPA cases from diseased controls (234 screened diseased controls). ROC curve analyses were performed and optimal cutoffs identified by Youden J statistic. CPA versus control ROC area under curve (AUC) results were: healthy controls 0.984 (95% confidence interval 0.972-0.997), diseased controls 0.972 (0.959-0.985), screened diseased controls 0.979 (0.967-0.992). Optimal cutoffs were: heal...Continue Reading

References

Sep 17, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David W DenningHelen Sambatakou
Jul 3, 2010·The European Respiratory Journal·N L Smith, D W Denning
Jan 25, 2012·Bulletin of the World Health Organization·David W DenningDonald C Cole
Feb 22, 2012·Respiratory Medicine·Hisano OhbaKingo Chida
Apr 14, 2012·Interactive Cardiovascular and Thoracic Surgery·Qian-Kun ChenJia-An Ding
Jun 30, 2012·The European Respiratory Journal·David W DenningDonald C Cole
Aug 29, 2012·Diagnostic Microbiology and Infectious Disease·Albert W van Toorenenbergen
Dec 13, 2012·Annals of the New York Academy of Sciences·Ales ChrdleDavid W Denning
Jan 22, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C G BaxterM D Richardson
Jun 4, 2013·The Journal of Allergy and Clinical Immunology·Caroline G BaxterDavid W Denning
Jun 22, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Khaled Al-ShairDavid W Denning
Jul 10, 2013·Medical Mycology·Byung Woo JhunWon-Jung Koh
Dec 5, 2013·Mycoses·K E SchweerO A Cornely
May 17, 2015·Medical Mycology·Iain D PageDavid W Denning
Dec 25, 2015·The European Respiratory Journal·David W DenningUNKNOWN European Society for Clinical Microbiology and Infectious Diseases and European Respiratory Society
Jul 2, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas F PattersonJohn E Bennett
Aug 20, 2016·BMC Pulmonary Medicine·Eavan G MuldoonDavid W Denning
Nov 7, 2016·Medical Mycology·Malcolm D Richardson, Iain D Page

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Citations

Feb 2, 2019·The European Respiratory Journal·Iain D PageDavid W Denning
Apr 7, 2020·Expert Review of Respiratory Medicine·Inderpaul Singh SehgalRitesh Agarwal
Oct 9, 2018·Current Fungal Infection Reports·Malcolm Richardson, Iain Page
Aug 17, 2020·Journal of Microbiological Methods·Bayu A P WilopoDavid W Denning

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Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.