Sigma-1 Receptor Antagonist Haloperidol Attenuates Store-Dependent Ca2+ Entry in Macrophages

Doklady. Biochemistry and Biophysics
Z I KrutetskayaA D Nozdrachev

Abstract

Using Fura-2AM microfluorimetry, we have shown for the first time that preincubation of macrophages with sigma-1 receptor antagonist haloperidol leads to a significant inhibition of the store-dependent Ca2+ entry induced by endoplasmic Ca2+-ATPase inhibitors thapsigargin or cyclopiazonic acid in rat peritoneal macrophages. The results suggest the involvement of the sigma-1 receptor in the regulation of storedependent Ca2+ entry in macrophages.

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Citations

Apr 29, 2020·Doklady. Biochemistry and Biophysics·Z I KrutetskayaA D Nozdrachev
Oct 30, 2018·Journal of the American Heart Association·Chowdhury S AbdullahMd Shenuarin Bhuiyan

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