Sigma receptors: potential medications development target for anti-cocaine agents

European Journal of Pharmacology
Rae R MatsumotoDaniel J Brackett

Abstract

The ability of cocaine to interact with sigma receptors suggests a viable target for medications development. Recently, numerous novel compounds and antisense oligodeoxynucleotides targeting sigma receptors have been synthesized and shown to prevent the behavioral toxicity and psychomotor stimulant effects of cocaine in animals. Protective doses of sigma receptor antagonists have also been shown to prevent changes in gene expression that are induced by cocaine. Together, the studies provide insight and promising future directions for the development of potential medications for the treatment of cocaine addiction and overdose.

References

Mar 1, 1992·Trends in Pharmacological Sciences·R QuirionD P Taylor
Aug 29, 1991·European Journal of Pharmacology·M MenkelJ M Witkin
Jul 1, 1991·Trends in Neurosciences·M J KuharJ W Boja
Mar 1, 1990·Neurology·A Pascual-LeoneD C Anderson
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M P KavanaughE Weber
Jan 1, 1987·Synapse·P C ContrerasT L O'Donohue
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·F P MonnetE E Baulieu
Nov 3, 1995·European Journal of Pharmacology·M NovakovaY Eilam
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·M HannerH Glossmann
Jan 25, 1996·European Journal of Pharmacology·H UjikeS Otsuki
Dec 1, 1995·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M HascoetJ L Peglion
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·I SoraG R Uhl
Sep 15, 1998·Human Molecular Genetics·G Rotman, Y Shiloh
Apr 9, 1999·Nature Neuroscience·B A RochaM G Caron

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Citations

Nov 6, 2004·Breast Cancer Research and Treatment·B WangL Pusztai
Aug 23, 2006·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Rikki N WaterhouseJon C Mirsalis
Jul 19, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Shilpa BuchJohn Wang
Feb 14, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Blaise Mathias CostaShilpa Buch
Apr 22, 2004·Pharmacology, Biochemistry, and Behavior·Rae R MatsumotoWayne D Bowen
Feb 25, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Valentina SabinoEric P Zorrilla
Jun 21, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pietro CottoneValentina Sabino
Jun 16, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sunmee WeeWilliam L Woolverton
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Gemma NavarroRafael Franco
Nov 7, 2009·The Journal of Pharmacology and Experimental Therapeutics·Takato HiranitaJonathan L Katz
Jan 27, 2010·The Journal of Pharmacology and Experimental Therapeutics·Yan-Tong XuRae R Matsumoto
Mar 25, 2011·Future Medicinal Chemistry·Sanju NarayananChristopher R McCurdy
Oct 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Teruo Hayashi, Tsung-Ping Su
Aug 21, 2010·Expert Opinion on Therapeutic Targets·Md Shenuarin BhuiyanKohji Fukunaga
Jun 4, 2015·Expert Opinion on Drug Discovery·Mellar P Davis
Aug 30, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Rae R MatsumotoAndrew Coop
Mar 23, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jiajia WangRae R Matsumoto
Aug 19, 2011·Chemical Biology & Drug Design·Mine YarimBernard Wünsch
Jan 31, 2012·Brain Research·Robert R LuedtkeJames W Simpkins
May 18, 2004·European Journal of Pharmacology·Rae R MatsumotoAndrew Coop
Dec 14, 2007·Expert Opinion on Therapeutic Targets·Teruo Hayashi, Tsung-Ping Su
Jun 10, 2015·Journal of Receptor and Signal Transduction Research·Colin G Rousseaux, Stephanie F Greene
Apr 8, 2015·Behavioural Brain Research·Angelo BlasioValentina Sabino
Jul 31, 2013·Pharmacology, Biochemistry, and Behavior·Andrew S SageDennis K Miller
Oct 31, 2006·European Journal of Pharmacology·Matthew K BrammerRae R Matsumoto
May 26, 2004·Bioorganic & Medicinal Chemistry·Stephan Bedürftig, Bernhard Wünsch
Nov 9, 2007·European Journal of Medicinal Chemistry·Susan L MercerAndrew Coop

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