Sigma receptors [σRs]: biology in normal and diseased states

Journal of Receptor and Signal Transduction Research
Colin G Rousseaux, Stephanie F Greene


This review compares the biological and physiological function of Sigma receptors [σRs] and their potential therapeutic roles. Sigma receptors are widespread in the central nervous system and across multiple peripheral tissues. σRs consist of sigma receptor one (σ1R) and sigma receptor two (σ2R) and are expressed in numerous regions of the brain. The sigma receptor was originally proposed as a subtype of opioid receptors and was suggested to contribute to the delusions and psychoses induced by benzomorphans such as SKF-10047 and pentazocine. Later studies confirmed that σRs are non-opioid receptors (not an µ opioid receptor) and play a more diverse role in intracellular signaling, apoptosis and metabolic regulation. σ1Rs are intracellular receptors acting as chaperone proteins that modulate Ca2+ signaling through the IP3 receptor. They dynamically translocate inside cells, hence are transmembrane proteins. The σ1R receptor, at the mitochondrial-associated endoplasmic reticulum membrane, is responsible for mitochondrial metabolic regulation and promotes mitochondrial energy depletion and apoptosis. Studies have demonstrated that they play a role as a modulator of ion channels (K+ channels; N-methyl-d-aspartate receptors [NMDAR];...Continue Reading


Oct 1, 1979·Clinical Pharmacology and Therapeutics·V Peck, L Shenkman
Nov 1, 1992·Quarterly Reviews of Biophysics·H Betz
Jan 1, 1992·Annual Review of Physiology·G P Gasic, M Hollmann
Mar 1, 1992·Trends in Pharmacological Sciences·R QuirionD P Taylor
Jan 1, 1992·The Journal of Physiology·B Nilius, W Wohlrab
Dec 1, 1992·Toxicology Letters·P Krogsgaard-Larsen, J J Hansen
Dec 1, 1992·European Journal of Pharmacology·D L DeHaven-HudkinsF Y Ford-Rice
Nov 1, 1992·Journal of Neurobiology·D W Choi
Nov 1, 1992·British Journal of Pharmacology·J H ConnickC D Nicholson
Oct 1, 1992·Endocrinology·P Lindström, L Ohlsson
Jul 1, 1992·Biological Psychology·F MartinR Dick
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J F FloodE Roberts
Mar 1, 1991·Brain Research Bulletin·M J PontecorvoJ W Ferkany
Sep 15, 1991·European Journal of Biochemistry·T P Su
Dec 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·V I Teichberg
Nov 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D R Burt, G L Kamatchi
Aug 6, 1991·European Journal of Pharmacology·J L JunienX Pascaud
Nov 1, 1991·Trends in Pharmacological Sciences·S L Erdö
Sep 17, 1991·European Journal of Pharmacology·J M Ffrench-Mullen, K T Spence
Aug 29, 1991·European Journal of Pharmacology·M MenkelJ M Witkin

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antisense oligonucleotides
reverse transcription PCR
confocal microscopy
light microscopy

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