Signal amplification in a microchannel from redox cycling with varied electroactive configurations of an individually addressable microband electrode array.

Analytical Chemistry
Penny M LewisIngrid Fritsch

Abstract

Amperometric detection at microelectrodes in lab-on-a-chip (LOAC) devices lose advantages in signal-to-background ratio, reduced ohmic iR drop, and steady-state signal when volumes are so small that diffusion fields reach the walls before flux becomes fully radial. Redox cycling of electroactive species between multiple, closely spaced microelectrodes offsets that limitation and provides amplification capabilities. A device that integrates a microchannel with an individually addressable microband electrode array has been used to study effects of signal amplification due to redox cycling in a confined, static solution with different configurations and numbers of active generators and collectors. The microfabricated device consists of a 22 microm high, 600 microm wide microchannel containing an array of 50 microm wide, 600 microm long gold microbands, separated by 25 microm gaps, interspersed with an 800 microm wide counter electrode and 400 microm wide passive conductor, with a distant but on-chip 400 microm wide pseudoreference electrode. Investigations involve solutions of potassium chloride electrolyte containing potassium ferrocyanide. Amplification factors were as high as 7.60, even with these microelectrodes of fairly larg...Continue Reading

References

Nov 16, 2001·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·P JinH Misawa
Jul 26, 2002·Analytical Chemistry·Zoraida P AguilarIngrid Fritsch
May 2, 2003·Analytical Chemistry·Kosei UenoNoboru Kitamura
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Citations

Nov 20, 2013·Nanoscale·Martin HüskeBernhard Wolfrum
Aug 28, 2014·Beilstein Journal of Nanotechnology·Enno KätelhönBernhard Wolfrum
Sep 14, 2011·Lab on a Chip·Nicholas M ContentoPaul W Bohn
Jul 8, 2010·ACS Medicinal Chemistry Letters·Hua MaoRobert E Gawley
Jun 13, 2013·Journal of the American Chemical Society·Enno KätelhönBernhard Wolfrum

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