Signal and noise in P300 recordings to visual stimuli

Documenta Ophthalmologica. Advances in Ophthalmology
Sven P Heinrich, Michael Bach

Abstract

The P300 of the event-related potential is typically obtained for infrequent target stimuli that are embedded in a sequence of frequent irrelevant stimuli. The P300 has been suggested as a marker of high-level cognitive processing and might be useful in ophthalmology to confirm the diagnosis of a functional disorder. However, typical P300 measurements require relatively lengthy recording sessions. It would therefore be desirable to minimize the required time and to maximize the signal-to-noise ratio by finding the optimal balance between parameters such as stimulus probability and the number of target trials or the recording time. This is different from previous studies, which assessed the amplitude only. We recorded event-related potentials to visual stimuli using standard oddball paradigms with various target frequencies ranging from 2:1 (target majority) to 1:16 (massive non-target majority). We compared the signal-to-noise ratios for a fixed number of target trials as well as for a fixed total recording time and assessed effects of the immediate stimulus history. As expected, P300 amplitudes depend strongly on target infrequency. This did not reach saturation within the range tested. For a given number of target trials, the...Continue Reading

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Citations

Mar 22, 2014·Documenta Ophthalmologica. Advances in Ophthalmology·David J MarhöferSven P Heinrich
Jan 17, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Gabriel PiresMiguel Castelo-Branco
Aug 16, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Styrmir SaevarssonSven P Heinrich
Aug 13, 2008·Journal of Neuroscience Methods·Dominik MellSven P Heinrich
May 9, 2014·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Boyla O MainsahChandra S Throckmorton
May 16, 2015·Documenta Ophthalmologica. Advances in Ophthalmology·David J MarhöferSven P Heinrich
Apr 20, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sven P HeinrichMichael Bach
Jan 15, 2015·Journal of Neural Engineering·B O MainsahC S Throckmorton

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