Apr 22, 2020

Astrocytes and neurons share brain region-specific transcriptional signatures

BioRxiv : the Preprint Server for Biology
A. Herrero-NavarroGuillermina Lopez-Bendito

Abstract

Neuronal cell diversity is essential to endow distinct brain regions with specific functions. During development, progenitors within these regions are characterised by specific gene expression programs, contributing to the generation of diversity in postmitotic neurons and glia. While the region-specific molecular diversity of neurons and astrocytes is increasingly understood, whether these cells share region-specific programs remains unknown. Here, we show that in the neocortex and thalamus, neurons and astrocytes express shared region-specific transcriptional and epigenetic signatures. These signatures not only distinguish cells across brain regions but are also detected across substructures within regions, such as distinct thalamic nuclei, where clonal analysis revealed the existence of common nucleus-specific progenitors for neurons and glia. Consistent with their shared molecular signature, regional specificity was maintained following astrocyte-to-neuron reprogramming. A detailed understanding of these regional-specific signatures may thus inform strategies for future cell-based brain repair.

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Mentioned in this Paper

Polyubiquitination
Theoretical Model
DNA Repair
Laptm5 protein, mouse
APC gene
Ubiquitin
Transcription Initiation
KITLG
Ubiquitin Activity
Cell Cycle

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