PMID: 8952562Dec 15, 1996Paper

Signal characteristics of tumors shown by high-resolution endorectal coil magnetic resonance imaging may predict outcome among patients with cervical carcinoma treated with irradiation. A preliminary study

Cancer
B W CornL J Solin

Abstract

The purpose of this study was to evaluate the role of high-resolution magnetic resonance imaging with the endorectal coil (eMRI) in the management of cervical carcinoma treated with definitive irradiation. Eighteen patients with invasive cervical carcinoma (International Federation of Gynecology and Obstetrics Stages Ib-IIIb) consented to evaluation with eMRI on a 1.5 tesla system with high resolution (400 x 400 microM). Images were read to provide staging information and to grade the signal characteristics of the individual tumors as low (dark), intermediate, or high (bright) relative to surrounding isointense fat. Patients were treated with standard megavoltage irradiation (prescribed dose, 80-85 Gray); shaped antero-posterior/postero-anterior or 4-field box techniques, plus brachytherapy, were used. In 39% of patients, tumors were determined to be in a higher stage by eMRI because of proximal vaginal involvement (n = 4) or the combination of proximal vaginal involvement and parametrial extension (n = 3). Features predictive of improved local control and survival without evidence of disease included stage, hemoglobin levels > or = 11, complete response to external irradiation, and bright signal characteristics. Compared with ...Continue Reading

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Citations

Feb 3, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Johannes C A DimopoulosRichard Pötter

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