PMID: 2493741Mar 1, 1989Paper

Signal for induction of aldose reductase in renal medullary cells by high external NaCl

The American Journal of Physiology
S UchidaM Burg

Abstract

GRB-PAP1 is a continuous line of epithelial cells derived from rabbit renal inner medulla. These cells accumulate large amounts of sorbitol when extracellular NaCl concentration is elevated. The accumulation involves an increase in aldose reductase, an enzyme that catalyzes production of sorbitol from glucose. The purpose of the present studies was to investigate the mechanism by which high NaCl triggers an increase in aldose reductase activity. When NaCl was added to increase medium osmolality from 300 to 500 mosmol/kg, enzyme activity began to increase after 12-24 h, was half-maximal in 2 days, and was maximal by 4 days. To test the effect of other solutes, medium osmolality was increased to 500 mosmol/kg by adding raffinose, urea, or glycerol. Raffinose increased aldose reductase activity as much as NaCl did. In contrast, neither urea nor glycerol affected the enzyme activity. NaCl and raffinose caused a sustained decrease in cell water content and an increase in cell sodium and potassium concentration, but urea did not. In some experiments, ouabain was added either with or without an increase in osmolality. Taking into account all of the experiments, with and without ouabain, we found that aldose reductase activity did not ...Continue Reading

References

Jan 1, 1988·Comparative Biochemistry and Physiology. A, Comparative Physiology·K R Spring, A W Siebens
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S M BagnascoM B Burg
Feb 1, 1987·Kidney International·R S Balaban, M B Burg
Sep 24, 1982·Science·P H YanceyG N Somero

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Citations

Jan 1, 1991·The Journal of Membrane Biology·A Garcia-Perez, M B Burg
Jul 1, 1996·Journal of Cellular Physiology·C LibioulleR Gilles
Jan 1, 1997·Annual Review of Physiology·M B BurgD Kültz
Jun 1, 1997·Glia·C Jacquin-Becker, G Labourdette
Jun 6, 2000·American Journal of Physiology. Cell Physiology·Y MiyataY Asano
Jun 3, 2000·American Journal of Physiology. Renal Physiology·S K WooH M Kwon
Jun 15, 2004·The Journal of Physiology·Joan D Ferraris, Maurice B Burg
Nov 4, 2004·American Journal of Physiology. Renal Physiology·David Sheikh-Hamad, Michael C Gustin
Dec 1, 1990·Hypertension·A Garcia-Perez, M B Burg
May 18, 1999·The American Journal of Physiology·W C O'Neill
Jul 18, 2000·American Journal of Physiology. Cell Physiology·D Sheikh-HamadM L Entman
Mar 11, 2000·American Journal of Physiology. Renal Physiology·D Sheikh-HamadY Yang
Feb 1, 1994·The Journal of Experimental Zoology·M B Burg
Aug 2, 1996·The Journal of Biological Chemistry·J D FerrarisA García-Pérez
Jan 1, 1991·Journal of Cellular Physiology·P A WhitsonC F Sams
Feb 11, 1998·Physiological Reviews·F LangD Häussinger
Jul 15, 1999·The Journal of Experimental Zoology·T R SmithT M Bradley
Oct 22, 2002·American Journal of Physiology. Cell Physiology·Wolfgang NeuhoferH Moo Kwon
Dec 5, 1998·The American Journal of Physiology·B C SantosS R Gullans
Oct 12, 2007·Physiological Reviews·Maurice B BurgNatalia I Dmitrieva
Dec 11, 1995·FEBS Letters·U WarskulatD Häussinger
Jun 25, 2005·Molecular & Cellular Proteomics : MCP·Hassan DihaziGerhard A Müller
Nov 17, 2004·Advances in Physiology Education·Kevin Strange
Jun 14, 2005·American Journal of Physiology. Renal Physiology·Natalia I DmitrievaJoan D Ferraris
Jul 1, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·J S Handler, H M Kwon
Mar 27, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·C LibioulleR Gilles
Jul 17, 1999·Brain Research. Molecular Brain Research·M NonakaT Hayakawa
Nov 6, 1998·Pharmacology & Therapeutics·A R Wright, S A Rees
Sep 28, 1998·Biochimica Et Biophysica Acta·L L Vieira
Sep 21, 2000·Kidney International. Supplement·M Dunlop
Jul 28, 2001·Kidney International·J S Handler, H M Kwon
Nov 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·S Edmands, P H Yancey
Jan 1, 1991·Comparative Biochemistry and Physiology. A, Comparative Physiology·R O Law
Dec 12, 1991·Biochimica Et Biophysica Acta·D Häussinger, F Lang
Oct 1, 1992·Biochemical Medicine and Metabolic Biology·A Bhatnagar, S K Srivastava

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