Signal intensity alteration within infrapatellar fat pad predicts knee replacement within 5 years: data from the Osteoarthritis Initiative

Osteoarthritis and Cartilage
Kang WangDavid J Hunter

Abstract

To investigate whether infrapatellar fat pad (IPFP) signal intensity (SI) alteration predicts the occurrence of knee replacement (KR) in knee osteoarthritis (OA) patients over 5 years. The subjects were selected from Osteoarthritis Initiative (OAI) study. Case knees (n = 127) were defined as those who received KR during 5 years follow-up visit. They were matched by gender, age and radiographic status with control knees (n = 127). We used T2-weighted MR images to measure IPFP SI alteration using a newly developed algorithm in MATLAB. The measurements were assessed at baseline (BL), T0 (the visit just before KR) and 1 year before T0 (T-1). Conditional logistic regression was used to analyse the associations between IPFP SI alterations and the risk of KR. Participants were mostly female (57%), with an average age of 63.7 years old and a mean body mass index (BMI) of 29.5 kg/m2. In multivariable analysis, the standard deviation (SD) of IPFP SI [sDev (IPFP)] and the ratio of high SI region volume to whole IPFP volume [Percentage (H)] measured at BL were significantly associated with increased risks of KR after adjustment for covariates. IPFP SI alterations measured at T-1 including sDev (IPFP), Percentage (H) and clustering effect o...Continue Reading

Citations

Feb 27, 2020·Postgraduate Medicine·Francis Berenbaum, Chris Walker
Nov 14, 2020·Current Opinion in Rheumatology·Natalia Zapata-LinaresXavier Houard
Dec 27, 2019·Osteoarthritis and Cartilage·R KijowskiA Guermazi
Oct 6, 2020·Aging and Disease·Ni ZengGuo-Xin Ni
Sep 26, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Zuoqing ZhouChanghai Ding

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