Signal intensity at unenhanced T1-weighted magnetic resonance in the globus pallidus and dentate nucleus after serial administrations of a macrocyclic gadolinium-based contrast agent in children

Pediatric Radiology
Maria Camilla Rossi EspagnetAntonio Napolitano

Abstract

Few studies have been conducted on the relations between T1-weighted signal intensity changes in the pediatric brain following gadolinium-based contrast agent (GBCA) exposure. The purpose of this study is to investigate the effect of multiple administrations of a macrocyclic GBCA on signal intensity in the globus pallidus and dentate nucleus of the pediatric brain on unenhanced T1-weighted MR images. This retrospective study included 50 patients, mean age: 8 years (standard deviation: 4.8 years), with normal renal function exposed to ≥6 administrations of the same macrocyclic GBCA (gadoterate meglumine) and a control group of 59 age-matched GBCA-naïve patients. The globus pallidus-to-thalamus signal intensity ratio and dentate nucleus-to-pons signal intensity ratio were calculated from unenhanced T1-weighted images for both patients and controls. A mixed linear model was used to evaluate the effects on signal intensity ratios of the number of GBCA administrations, the time interval between administrations, age, radiotherapy and chemotherapy. T-test analyses were performed to compare signal intensity ratio differences between successive administrations and baseline MR signal intensity ratios in patients compared to controls. P-v...Continue Reading

References

Apr 21, 2006·European Radiology·N Martin-DuverneuilUNKNOWN French Langerhans Cell Histiocytosis Study Group
Nov 13, 2008·Investigative Radiology·Thomas FrenzelHanns-Joachim Weinmann
Jan 23, 2009·Journal of the American Society of Nephrology : JASN·George J SchwartzSusan L Furth
Nov 26, 2009·Journal of Magnetic Resonance Imaging : JMRI·Silvio Aime, Peter Caravan
Apr 24, 2013·Neuroimaging Clinics of North America·Helen M Branson
Mar 6, 2015·Radiology·Robert J McDonaldLaurence J Eckel
Aug 22, 2015·AJNR. American Journal of Neuroradiology·M E AdinD M Yousem
Dec 15, 2015·AJNR. American Journal of Neuroradiology·J RamalhoM Castillo
Dec 27, 2015·La Radiologia medica·Bruno Beomonte ZobelRosario Francesco Grasso

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Citations

Jul 22, 2017·Journal of Magnetic Resonance Imaging : JMRI·Simona BussiFederico Maisano
Mar 7, 2018·CNS Drugs·Luca PasquiniMaria Camilla Rossi Espagnet
Sep 16, 2017·Pediatric Radiology·Alexander Radbruch, Carlo Cosimo Quattrocchi
Mar 11, 2018·Clinical Neuroradiology·Richard PullicinoKumar Das
Mar 6, 2018·Journal of Magnetic Resonance Imaging : JMRI·Michael Hunter LanierGeetika Khanna
Dec 6, 2018·Metallomics : Integrated Biometal Science·Mariane Le Fur, Peter Caravan
Jun 6, 2019·Pediatric Radiology·Carlos F Ugas CharcapeMonica Epelman
Dec 22, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Axel MontagneBerislav V Zlokovic
Oct 31, 2019·Journal of Magnetic Resonance Imaging : JMRI·Elif Dilara TopcuogluYasar Bukte
Feb 26, 2020·AJR. American Journal of Roentgenology·Mark A AndersonMichael S Gee
Nov 11, 2018·European Radiology·Carlo C QuattrocchiUNKNOWN GREC, European Gadolinium Retention Evaluation Consortium and the ESNR, European Society of Neuroradiology
Aug 10, 2019·Clinical Rheumatology·Liete Figueiredo ZwirArtur Rocha Corrêa Fernandes
Nov 16, 2019·AJNR. American Journal of Neuroradiology·D S EnterlineC Colosimo
Mar 1, 2019·International Journal of Molecular Sciences·Alessandro Fulgenzi, Maria Elena Ferrero
Jul 25, 2020·Biophysics Reviews·Summer HassanDavid J Crossman
Aug 6, 2018·Pediatric Radiology·Michael N Rozenfeld, Daniel J Podberesky
Nov 5, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nikolas M DammeKathryn A Morton
May 5, 2018·La Radiologia medica·Sergio SalernoPaolo Tomà

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