Signal processing by T-type calcium channel interactions in the cerebellum

Frontiers in Cellular Neuroscience
Jordan D T EngbersRay W Turner

Abstract

T-type calcium channels of the Cav3 family are unique among voltage-gated calcium channels due to their low activation voltage, rapid inactivation, and small single channel conductance. These special properties allow Cav3 calcium channels to regulate neuronal processing in the subthreshold voltage range. Here, we review two different subthreshold ion channel interactions involving Cav3 channels and explore the ability of these interactions to expand the functional roles of Cav3 channels. In cerebellar Purkinje cells, Cav3 and intermediate conductance calcium-activated potassium (IKCa) channels form a novel complex which creates a low voltage-activated, transient outward current capable of suppressing temporal summation of excitatory postsynaptic potentials (EPSPs). In large diameter neurons of the deep cerebellar nuclei, Cav3-mediated calcium current (I T) and hyperpolarization-activated cation current (I H) are activated during trains of inhibitory postsynaptic potentials. These currents have distinct, and yet synergistic, roles in the subthreshold domain with I T generating a rebound burst and I H controlling first spike latency and rebound spike precision. However, by shortening the membrane time constant the membrane return...Continue Reading

Citations

Dec 17, 2014·Frontiers in Cellular Neuroscience·Leigh A SwayneGerald W Zamponi
Dec 3, 2014·Bio Systems·Hiroyuki Ohta
Nov 8, 2018·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·JooHan WooJoo Hyun Nam
Aug 15, 2018·Frontiers in Molecular Neuroscience·Aravind S KshatriTeresa Giraldez
May 10, 2018·Frontiers in Cellular Neuroscience·Przemysław KurowskiPaweł Szulczyk
May 16, 2018·Frontiers in Synaptic Neuroscience·Eriola HoxhaFilippo Tempia
Sep 4, 2020·International Journal of Molecular Sciences·Géza BereckiSteven Petrou

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BETA
coimmunoprecipitation

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