Signal propagation via cortical hierarchies

Network Neuroscience
Bertha Vázquez-RodríguezBratislav Misic

Abstract

The wiring of the brain is organized around a putative unimodal-transmodal hierarchy. Here we investigate how this intrinsic hierarchical organization of the brain shapes the transmission of information among regions. The hierarchical positioning of individual regions was quantified by applying diffusion map embedding to resting-state functional MRI networks. Structural networks were reconstructed from diffusion spectrum imaging and topological shortest paths among all brain regions were computed. Sequences of nodes encountered along a path were then labeled by their hierarchical position, tracing out path motifs. We find that the cortical hierarchy guides communication in the network. Specifically, nodes are more likely to forward signals to nodes closer in the hierarchy and cover a range of unimodal and transmodal regions, potentially enriching or diversifying signals en route. We also find evidence of systematic detours, particularly in attention networks, where communication is rerouted. Altogether, the present work highlights how the cortical hierarchy shapes signal exchange and imparts behaviorally relevant communication patterns in brain networks.

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Citations

Dec 18, 2020·ELife·Golia ShafieiBratislav Misic
Nov 17, 2020·Network Neuroscience·Daniel GrahamBratislav Mišić
Jun 9, 2021·Biological Psychiatry·Linden ParkesDanielle S Bassett
Jul 23, 2021·Science Advances·Ryan V RautMarcus E Raichle

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Software Mentioned

Connectome Mapper Toolkit
FreeSurfer
Brainconn Python Toolbox
Dimensionality Reduction Toolbox

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