Signal-to-noise analysis of cerebral blood volume maps from dynamic NMR imaging studies

Journal of Magnetic Resonance Imaging : JMRI
J L BoxermanR M Weisskoff

Abstract

The use of cerebral blood volume (CBV) maps generated from dynamic MRI studies tracking the bolus passage of paramagnetic contrast agents strongly depends on the signal-to-noise ratio (SNR) of the maps. The authors present a semianalytic model for the noise in CBV maps and introduce analytic and Monte Carlo techniques for determining the effect of experimental parameters and processing strategies upon CBV-SNR. CBV-SNR increases as more points are used to estimate the baseline signal level. For typical injections, maps made with 10 baseline points have 34% more noise than those made with 50 baseline points. For a given peak percentage signal drop, an optimum TE can be chosen that, in general, is less than the baseline T2. However, because CBV-SNR is relatively insensitive to TE around this optimum value, choosing TE approximately equal to T2 does not sacrifice much SNR for typical doses of contrast agent. The TR that maximizes spin-echo CBV-SNR satisfies TR/T1 approximately equal to 1.26, whereas as short a TR as possible should be used to maximize gradient-echo CBV-SNR. In general, CBV-SNR is maximized for a given dose of contrast agent by selecting as short an input bolus duration as possible. For image SNR exceeding 20-30, th...Continue Reading

References

Feb 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T H Foster
Dec 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B R RosenM S Cohen
Feb 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A VillringerT J Brady
Feb 1, 1970·Journal of Applied Physiology·C F Starmer, D O Clark
Mar 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M M Bahn
May 1, 1994·Journal of Computer Assisted Tomography·F GückelM Georgi
Oct 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M TakahashiH Ogawa
Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J L BoxermanR M Weisskoff
Feb 1, 1991·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·J W BelliveauB R Rosen
Jun 1, 1964·Circulation Research·H K THOMPSONH D MCINTOSH

❮ Previous
Next ❯

Citations

Dec 18, 2001·Journal of Magnetic Resonance Imaging : JMRI·A JacksonK L Li
Jun 23, 2010·European Radiology·Frederik L GieselMarco Essig
Jul 2, 2003·Clinical Radiology·P KestonA Jackson
Jun 6, 2000·Advanced Drug Delivery Reviews·N J AbbottE H Lo
Jan 15, 1999·Magnetic Resonance Imaging· Frederick B deBP F Renshaw
Apr 12, 2003·Neuroimaging Clinics of North America·F Zerrin Yetkin, Dianne Mendelsohn
Jul 21, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F CalamanteR Turner
Nov 19, 2004·Topics in Magnetic Resonance Imaging : TMRI·Rudolf Stollberger, Franz Fazekas
Jan 29, 2005·The British Journal of Radiology·A Jackson
Apr 30, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jussi PerkiöLeif Østergaard
Mar 29, 2001·Journal of Magnetic Resonance Imaging : JMRI·E L BarbierM Décorps
Dec 20, 2005·Neuroimaging Clinics of North America·Ona WuA Gregory Sorensen
May 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C C QuarlesK M Schmainda
Aug 17, 2005·Journal of Magnetic Resonance Imaging : JMRI·Jean J ChenRichard Frayne
Dec 4, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ka-Loh Li, Alan Jackson
Dec 20, 2008·Journal of Magnetic Resonance Imaging : JMRI·Jeffry R AlgerS Chelsea Kidwell
Feb 4, 2006·Journal of Magnetic Resonance Imaging : JMRI·Michael C LeeSarah J Nelson
May 13, 2014·Journal of Magnetic Resonance Imaging : JMRI·Mark S ShiroishiMeng Law
Apr 12, 2003·Neuroimaging Clinics of North America·Hannu J Aronen, Jussi Perkiö
Sep 14, 2015·Neuro-oncology·Mark S ShiroishiWhitney B Pope
Apr 25, 2015·AJNR. American Journal of Neuroradiology·K WelkerUNKNOWN American Society of Functional Neuroradiology MR Perfusion Standards and Practice Subcommittee of the ASFNR Clinical Practic
Oct 16, 2016·Magnetic Resonance Imaging Clinics of North America·Jerrold L BoxermanWhitney B Pope
Sep 20, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G ZaharchukB R Rosen
Mar 7, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Heiko SchmiedeskampRoland Bammer
Jun 17, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·O SpeckT Ernst
Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alina TudoricaGeorge C Newman
Sep 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F CalamanteA Connelly

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved