Signal transducer and activator of transcription 4 in liver diseases

International Journal of Biological Sciences
Yan WangHua Wang

Abstract

STAT4 is a member of the signal transducer and activator of transcription (STAT) family of molecules that localizes to the cytoplasm. STAT4 regulates various genes expression as a transcription factor after it is phosphorylated, dimerizes and translocates to the nucleus. STAT4 activation is detected virtually in the liver of several mouse models of liver injury, as well as the human liver of chronic liver diseases. STAT4 gene polymorphism has been shown to be associated with the antiviral response in chronic hepatitis C and drug-induced liver injury (DILI), primary biliary cirrhosis (PBC), HCV-associated liver fibrosis and in hepatocellular carcinoma (HCC). However, the roles of STAT4 in the pathogeneses of liver diseases are still not understood entirely. This review summarizes the recent advances on the functional roles of STAT4 and its related cytokines in liver diseases, especially in regulating hepatic anti-viral responses, inflammation, proliferation, apoptosis and tumorigenesis. Targeting STAT4 signaling pathway might be a promising strategy in developing therapeutic approaches for treating hepatitis in order to prevent further injury like cirrhosis and liver cancer.

Citations

May 15, 2016·Immunology Letters·O Beltrán RamírezJ Ramírez Bello
Nov 1, 2016·Scandinavian Journal of Gastroenterology·Hairong ZhuXizhong Shen
Apr 30, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Li ZhangJiasheng Chen
Feb 7, 2018·Nature Reviews. Clinical Oncology·Daniel E JohnsonJennifer R Grandis
Aug 24, 2017·Journal of Clinical Laboratory Analysis·Jie ChenLanlan Wang
Jun 1, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Mengmeng ZhangJiajia Wang
Aug 19, 2017·Journal of Gastrointestinal Cancer·Yeliz YılmazNeşe Atabey
Apr 27, 2021·Cancer Biomarkers : Section a of Disease Markers·Xuan ZhongSidong Chen

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Methods Mentioned

BETA
ChIP
immunoprecipitation

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