Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses

Frontiers in Immunology
Elissa K DeenickCindy S Ma

Abstract

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of many key cytokine receptors expressed by lymphocytes. As such, it plays a critical role in regulating B cells as well as CD4+ and CD8+ T cells. Patients with clinically significant immunodeficiency and immune dysregulation resulting from loss-of-function or gain-of-function mutations in STAT3 have been described. These individuals provide insight into the critical role of this transcription factor in the regulation of immune responses and the balance between effective immune protection and autoimmunity.

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Citations

Apr 30, 2020·Immunology and Cell Biology·Elissa K DeenickAlisa Kane
May 15, 2020·Science Translational Medicine·Gemma MoncunillCarlota Dobaño
Sep 12, 2019·Scientific Reports·Mehmet Eren AhsenSupinda Bunyavanich
Mar 13, 2020·JCI Insight·Esra MeidanGeorge C Tsokos
Sep 19, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Li LinXiaochuan Wang
Dec 18, 2020·Frontiers in Pediatrics·Magda Carneiro-SampaioAntonio Coutinho
Apr 13, 2020·European Journal of Pharmacology·Tohid GharibiBehzad Baradaran
Mar 11, 2021·Microbial Pathogenesis·Abdollah JafarzadehSara Jafarzadeh
Aug 21, 2020·Molecular and Cellular Endocrinology·Mariana Gutiérrez
May 26, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Vijaya KnightNicholas L Rider
Aug 15, 2021·Immunologic Research·Lia Furlaneto MaregaMaria Marluce Dos Santos Vilela
Jul 25, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Wenbin WuSong Guo Zheng

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