Signal Transducer and Activator of Transcription Protein 3 (STAT3): An Update on its Direct Inhibitors as Promising Anticancer Agents

Current Medicinal Chemistry
Arianna GelainStefania Villa

Abstract

Since Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor which plays an important role in multiple aspects of cancer, including progression and migration, and it is constitutively activated in various human tumors, STAT3 inhibition has emerged as a validated strategy for the treatment of several malignancies. The aim of this review is to provide an update on the identification of new promising direct inhibitors targeting STAT3 domains, as potential anticancer agents. A thorough literature search focused on recently reported STAT3 direct inhibitors was undertaken. We considered the relevant developments regarding the STAT3 domains, which have been identified as potential drug targets. In detail, 135 peer-reviewed papers and 7 patents were cited; the inhibitors we took into account targeted the DNA binding domain (compounds were grouped into natural derivatives, small molecules, peptides, aptamers and oligonucleotides), the SH2 binding domain (natural, semi-synthetic and synthetic compounds) and specific residues, like cysteines (natural, semi-synthetic, synthetic compounds and dual inhibitors) and tyrosine 705. The huge number of direct STAT3 inhibitors recently identified demonstrates a strong ...Continue Reading

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Citations

May 6, 2019·Cancers·Samantha Kah Ling OngAnupam Bishayee
Oct 24, 2018·Oncotarget·Fiorella Meneghetti, Daniela Barlocco
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Feb 12, 2021·Journal of Medicinal Chemistry·Ross S ManciniMark A Reed

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