Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Y SekineT Matsuda

Abstract

Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2-like domains, as well as a YXXQ motif in its C-terminal region. Our previous studies revealed that STAP-2 regulates integrin-mediated T cell adhesion. In the present study, we find that STAP-2 expression affects Jurkat T cell migration after stromal cell-derived factor-1alpha (SDF-1alpha)-treatment. Furthermore, STAP-2-deficient T cells exhibit reduced cell migration after SDF-1alpha-treatment. Importantly, overexpression of STAP-2 in Jurkat T cells induces activation of small guanine triphosphatases, such as Rac1 and Cdc42. Regarding the mechanism for this effect, we found that STAP-2 associates with Vav1, the guanine-nucleotide exchanging factor for Rac1, and enhances downstream Vav1/Rac1 signaling. These results reveal a novel STAP-2-mediated mechanism for the regulation of SDF-1alpha-induced chemotaxis of T cells via activation of Vav1/Rac1 signaling.

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Citations

Oct 12, 2010·The Journal of Biological Chemistry·Osamu IkedaTadashi Matsuda
Jun 4, 2010·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yuichi Sekine
Oct 7, 2015·Stem Cell Research & Therapy·Michael J RuttenKenton W Gregory
Mar 13, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuichi SekineTadashi Matsuda
Apr 7, 2016·The Journal of Biological Chemistry·Sumihito TogiTadashi Matsuda
May 23, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuichi SekineTadashi Matsuda
Jan 20, 2021·Tropical Animal Health and Production·Lintong LuoFang Ma
Jul 2, 2021·Biological & Pharmaceutical Bulletin·Tadashi Matsuda, Kenji Oritani
Nov 16, 2021·Experimental Hematology·Michiko IchiiYuzuru Kanakura

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