PMID: 18411083Sep 1, 1989Paper

Signal transduction and the ras gene family: molecular switches of unknown function

Trends in Endocrinology and Metabolism : TEM
I G Macara, A Wolfman

Abstract

The ras family consists of 20 or more genes that encode small GTP/GDP-binding proteins, of 20-26 kDa, the functions of which are unknown. This article discusses possible roles of the ras proteins in signal transduction and the interaction of p21(ras) and other members of the ras family with GTPase-accelerating proteins (GAPS) that may be regulatory elements of the signaling machinery.

References

Jan 1, 1985·The American Journal of Physiology·I G Macara
Aug 15, 1988·Biochemical and Biophysical Research Communications·H KatoT Takenawa
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K FukamiT Takenawa
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J DownwardR A Weinberg
Jan 1, 1987·Annual Review of Biochemistry·A G Gilman
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J L Sewell, R A Kahn
Jan 15, 1988·Cell·C L YuD W Stacey
Jan 1, 1987·Annual Review of Biochemistry·M Barbacid
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·N TouchotA Tavitian
May 1, 1985·Cell·P Madaule, R Axel
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·I G MacaraP C Balduzzi

❮ Previous
Next ❯

Citations

Dec 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·A AmsterdamJ F Strauss
Sep 1, 1991·The Journal of protozoology·J B Peterson
Dec 1, 1992·Trends in Endocrinology and Metabolism : TEM·A SpadaG Faglia
Apr 1, 1990·British Journal of Industrial Medicine·R D Hamm
Jan 1, 1993·Molecular and Chemical Neuropathology·P Andiné
Dec 22, 2004·Nature Reviews. Neuroscience·Martin Lauritzen
May 1, 1995·Journal of Neurology·A GironellJ L Martí-Vilalta
Jan 13, 2016·Scientific Reports·Emeric ScharbargArmelle Rancillac
Oct 31, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Ulrike FronzDaniel-Christoph Wagner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.