Signal transduction as a drug-discovery platform

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Signal transduction as a drug-discovery platform

Abstract

References

An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates

Relation of chemotactic response to the amount of receptor: evidence for different efficiencies of signal transduction.

Requirement for c-ras proteins during viral oncogene transformation

Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate

Inhibition by cAMP of Ras-dependent activation of Raf

Lead validation platforms

Proteomics

Citations

Phosphoryltyrosyl mimetics in the design of peptide-based signal transduction inhibitors

Profiling signalling pathways of the receptor activator of NF-kappaB ligand-induced osteoclast formation in mouse monocyte cells, RAW264.7

Microfluidic interrogation and mathematical modeling of multi-regime calcium signaling dynamics

Life sciences on the Semantic Web: the Neurocommons and beyond

Phosphoproteomics identifies oncogenic Ras signaling targets and their involvement in lung adenocarcinomas.

Pathway proteomics: global and focused approaches

Database of cell signaling enzymes

Drug repositioning by applying 'expression profiles' generated by integrating chemical structure similarity and gene semantic similarity

Functional protein micropatterning for drug design and discovery

Using grid techniques for drug target identification

Artificial signal transduction therapy: a futuristic approach to disease treatment

Mathematical modeling and application of genetic algorithm to parameter estimation in signal transduction: trafficking and promiscuous coupling of G-protein coupled receptors

Peptide Immunoaffinity Enrichment and Targeted Mass Spectrometry Enables Multiplex, Quantitative Pharmacodynamic Studies of Phospho-Signaling.

Introduction to chemical proteomics for drug discovery and development

Signaling through non-membrane nuclear phosphoinositide binding proteins in human health and disease.

Cell microencapsulation with synthetic polymers

Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action

Role in neuronal cell migration for high-threshold potassium currents in the chicken hindbrain

Chemical biology approach for the development of hypoxia inducible factor (HIF) inhibitor LW6 as a potential anticancer agent

Integrative Data Analytic Framework to Enhance Cancer Precision Medicine.

Synthetic inhibitors of proline-rich ligand-mediated protein-protein interaction: potent analogs of UCS15A

Yeast glycogen synthase kinase-3beta pathway inhibitors from an organic extract of Streptomyces sp

Kinetic Study of Chiral Intermolecular Interactions by Moment Analysis Based on Affinity Capillary Electrophoresis

Evaluation of Migration Time and Variance for Accurate Kinetic Studies Based on Affinity Capillary Electrophoresis

Bioactive polybrominated diphenyl ethers from the marine sponge Dysidea sp

EXCESP: A Structure-Based Online Database for Extracellular Interactome of Cell Surface Proteins in Humans.

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Related Papers

Synthesis of novel chemical probes for the study of tanshinone binding proteins

Retraction signals end of cell-biology debate

Report backs Smithsonian research

Cyclic peptides incorporating 4-carboxyphenylalanine and phosphotyrosine are potent inhibitors of pp60(c-)(src)

Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome