Signal transduction by interleukin-12 and interleukin-2. A comparison and contrast

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Signal transduction by interleukin-12 and interleukin-2. A comparison and contrast

Abstract

References

Growth factor signaling by receptor tyrosine kinases.

Sequence similarity between NKSF and the IL-6/G-CSF family

A protein tyrosine kinase in the interferon alpha/beta signaling pathway

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

Cloning of the gamma chain of the human IL-2 receptor

An activating mutation in the murine erythropoietin receptor induces erythroleukemia in mice: a cytokine receptor superfamily oncogene.

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor

Interleukin-2-triggered Raf-1 expression, phosphorylation, and associated kinase activity increase through G1 and S in CD3-stimulated primary human T cells.

Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells

Structural design and molecular evolution of a cytokine receptor superfamily

The biology and clinical applications of interleukin 2

Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.

Interleukin-2: inception, impact, and implications

Three-dimensional structure of interleukin-2

Interleukin-2 induction of T-cell G1 progression and c-myb expression

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

Interleukin 2

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3

Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development

Defective lymphoid development in mice lacking Jak3

Differences in the interleukin-2 (IL-2) receptor system in human and mouse: alpha chain is required for formation of the functional mouse IL-2 receptor

Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases.

Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation

The Src-family kinase, Fyn, regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12

Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction

Transcription factors in interferon signaling

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

Signaling through the interleukin 2 receptor beta chain activates a STAT-5-like DNA-binding activity

Stat3 and Stat4: members of the family of signal transducers and activators of transcription

Phosphorylation of src family lck tyrosine kinase following interleukin-12 activation of human natural killer cells

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue

Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins

Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway

IL-2 signaling: recruitment and activation of multiple protein tyrosine kinases by the components of the IL-2 receptor

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

Cellular and molecular mechanisms of IFN-gamma production induced by IL-2 and IL-12 in a human NK cell line

Involvement of p59fynT in interleukin-5 receptor signaling

Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor.

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

Role of IRS-2 in insulin and cytokine signalling

Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain

Requirement of serine phosphorylation for formation of STAT-promoter complexes

Jaks and Stats in signaling by the cytokine receptor superfamily

The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam

Citations

Interleukin-10 inhibits polymethylmethacrylate particle induced interleukin-6 and tumor necrosis factor-alpha release by human monocyte/macrophages in vitro

Differential effect of a single high dose of the tricyclic antidepressant imipramine on interleukin-1beta and tumor necrosis factor-alpha secretion following an in vivo lipopolysaccharide challenge in rats

Interleukin-12 induces efficient lysis of natural killer-sensitive and natural killer-resistant human osteosarcoma cells: the synergistic effect of interleukin-2

Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

IL-12 plays a significant role in the apoptosis of human T cells in the absence of antigenic stimulation.

CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP

Dual roles of IL-22 at ischemia-reperfusion injury and acute rejection stages of rat allograft liver transplantation

Role of monocytes in atherogenesis

Salmonella infection does not increase expression and activity of the high affinity IL-12 receptor

STAT4 knockout mice are more susceptible to concanavalin A-induced T-cell hepatitis.

Related Concepts

Related Feeds

AKT Pathway

Related Papers

The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs

Interleukin-1 research

Apoptosis induced by NK cells is modulated by the NK-active cytokines IL-2 and IL-12

Systemic administration of rIL-12 synergistically enhances the therapeutic effect of a TNF gene-transduced cancer vaccine

Induction mechanism of human blood CD8+ T cell proliferation and cytotoxicity by natural killer cell stimulatory factor (interleukin-12)