PMID: 9660251Jul 11, 1998Paper

Signal transduction in LPS-activated aged and young monocytes

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
A D DelpedroO Bakouche

Abstract

Aged monocytes, that is, monocytes purified from the blood of donors > or =65 years of age, when compared with young monocytes, that is, monocytes purified from the blood of young donors 25 years of age, display a decrease in interleukin-6 (IL-6) and tumor necrosis factor (TNF) production after activation by lipopolysaccharide (LPS). The LPS concentration required to obtain IL-6 and TNF production is much higher for aged monocytes than for young monocytes. Furthermore, the intensity of TNF and IL-6 production was much weaker for LPS-activated aged monocytes than for LPS-activated young monocytes. In addition, deficient protein kinase C (PKC)-alpha, PKC-/betaI, and PKC-betaII activation, deficient mitogen-activated protein kinase (MAP-Kinase) activation, and deficient expression of c-Fos and c-Jun was observed in LPS-activated aged monocytes when compared with LPS-activated young monocytes. These data suggest that age induces human monocyte immune deficiencies that could be observed not only at the functional level but also in the signal transduction pathways.

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Citations

Feb 8, 2003·Experimental Eye Research·Victor M ElnerHoward R Petty
Feb 13, 2001·Mechanisms of Ageing and Development·L PulsatelliE Mariani
Jul 27, 2001·Mechanisms of Ageing and Development·E MarianiA Facchini
Apr 21, 2001·Archives of Gerontology and Geriatrics·L MalaguarneraM Malaguarnera
Feb 1, 2003·Experimental Gerontology·Jorge Lloberas, Antonio Celada
Dec 1, 2011·Sexual Health·Anna C HearpsSuzanne M Crowe
Sep 4, 2010·Antioxidants & Redox Signaling·Subramaniam Ponnappan, Usha Ponnappan
Nov 28, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·K SharmanS C Bondy
Nov 16, 2010·Ageing Research Reviews·Albert C ShawRuth R Montgomery
Jun 23, 2009·Trends in Immunology·Alexander PandaAlbert C Shaw
Jul 1, 2008·Experimental Gerontology·Christian R GomezElizabeth J Kovacs
Dec 11, 2007·Physiology & Behavior·Steven G KinseyDavid A Padgett
Feb 3, 2005·International Journal of Cardiology·Ramón Arroyo-EspligueroJuan Carlos Kaski
Oct 19, 2004·Experimental Gerontology·Marian L KohutJan A Moynihan
Sep 17, 2005·Immunobiology·Carlos SebastiánJorge Lloberas
Feb 12, 2014·Experimental Gerontology·Niharika Arora DuggalJanet M Lord
Jan 29, 2000·European Journal of Clinical Investigation·P Antal-Szalmás
Nov 14, 2012·Nature Reviews. Nephrology·Dianne McKay, Julie Jameson
May 31, 2001·The Journal of Biological Chemistry·H Saito, J Papaconstantinou
Aug 11, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Olivier DésySacha A De Serres
Nov 17, 2020·Frontiers in Immunology·Anna Julia PietrobonMaria Notomi Sato

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