PMID: 9159224Mar 15, 1997Paper

Signal transduction in pancreatic beta-cells: regulation of insulin secretion by information flow in the phospholipase C/protein kinase C pathway

Frontiers in Bioscience : a Journal and Virtual Library
Walter S ZawalichKathleen C Zawalich

Abstract

The physiologic regulation of glucose-induced insulin secretion is dependent upon the activation of information flow in the phospholipase C (PLC)/protein kinase C (PKC) signal transduction system. In both rat and human pancreatic beta-cells, glucose has several time-dependent effects on secretory responsiveness including the regulation of biphasic insulin secretion, time-dependent potentiation and time-dependent suppression. PLC/PKC activation has been implicated in all three response patterns. Islets of Langerhans contain the three major PLC isozyme classes (beta1, gamma1 and delta1) and the available evidence suggests that one class is activated by fuel secretagogues and another by neurohumoral agonists. The expression and activation of PLC is labile. When rat islet are cultured for short periods, the content and activation of PLC in response to glucose decreases and this biochemical defect in signal transduction is paralleled by significant reductions in glucose-induced insulin secretion. Similar defects are observed when human islets are cultured as well. Mouse islet responses to glucose stimulation differ in several major and dramatic ways from rat and human islet responses. When stimulated by 15mM glucose, mouse islets fa...Continue Reading

Citations

Dec 9, 1998·The American Journal of Physiology·F B LimaJ Cipolla-Neto
Jan 25, 2000·American Journal of Physiology. Endocrinology and Metabolism·T J Kieffer, J F Habener
Oct 27, 2005·American Journal of Physiology. Endocrinology and Metabolism·Craig S NunemakerLeslie S Satin
Oct 25, 2008·Archives of Biochemistry and Biophysics·Nathan L VanderfordSabire Ozcan
Apr 7, 2009·Cell Calcium·Damian B van Rossum, Randen L Patterson
Jun 23, 2009·European Journal of Pharmacology·Zhuo Fu, Dongmin Liu

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