Signal transduction in the Caenorhabditis elegans nervous system

Annual Review of Neuroscience
C I Bargmann, J M Kaplan

Abstract

Caenorhabditis elegans interacts with its environment by sensing chemicals, touch, and temperature; genetic analysis of each of these responses has led to the identification of candidate signaling molecules within sensory neurons. A molecular model for touch sensation has emerged from studies of the mechanosensory response; the receptors and signal transduction mechanisms in olfactory neurons are being elucidated; and an unusual neuroendocrine role for a TGF-beta-related peptide in chemosensory neurons has been discovered. Presynaptic and postsynaptic components of neuronal synapses have been identified in behavioral and pharmacological mutant screens. Mutations have been found in multiple classes of nicotinic acetylcholine receptor genes, excitatory and inhibitory glutamate receptor genes, and candidate gap junction genes, allowing their function to be studied in vivo. Different G-protein signaling pathways have characteristic effects on behavior, neuronal degeneration, and embryonic development.

References

Aug 10, 1976·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D G Albertson, J N Thomson
Aug 10, 1976·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J G WhiteS Brenner
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E M Hedgecock, R L Russell
Jun 1, 1975·Genetics·D B DusenberyR L Russell
Jul 1, 1992·Trends in Neurosciences·J O Pickles, D P Corey
Jul 1, 1992·Developmental Biology·T Watanabe, D R Kankel
Jan 1, 1991·Annual Review of Biochemistry·H G DohlmanR J Lefkowitz
Jan 1, 1990·Annual Review of Physiology·A M Brown, L Birnbaumer
Mar 1, 1991·Neuron·M V BennettJ C Sáez
Oct 20, 1990·Journal of Molecular Biology·I Fino Silva, R H Plasterk
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·C I BargmannH R Horvitz
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E C CropperK R Weiss
Mar 1, 1990·The Journal of Experimental Zoology·L Avery, H R Horvitz
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P G MorganP M Meneely
Nov 1, 1989·British Journal of Pharmacology·R J Martin, A J Pennington
Sep 1, 1989·Molecular and Cellular Biology·D Blinder, D D Jenness
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M D Whim, P E Lloyd
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B M Curtis, W A Catterall
Jan 1, 1985·Molecular & General Genetics : MGG·J W Golden, D L Riddle
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S Ward
May 1, 1974·Genetics·S Brenner
Apr 1, 1974·The Journal of Experimental Zoology·D B Dusenbery
May 28, 1982·Science·H R HorvitzP D Evans
Aug 1, 1980·Developmental Biology·J E Sulston, J G White
Apr 23, 1981·Nature·D L RiddleP S Albert
Mar 1, 1981·Developmental Biology·M Chalfie, J Sulston
May 20, 1981·The Journal of Comparative Neurology·P S AlbertD L Riddle

❮ Previous
Next ❯

Citations

Aug 26, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·T M Wilkie
Jun 14, 2005·Pflügers Archiv : European journal of physiology·Wolfgang Liedtke
Apr 28, 1999·Trends in Genetics : TIG·B C Prasad, R R Reed
Sep 12, 2000·Current Opinion in Neurobiology·C G Galizia, R Menzel
Oct 6, 1999·Current Opinion in Neurobiology·N J Strausfeld, J G Hildebrand
Apr 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Greg J StephensWilliam Bialek
Nov 12, 2002·The EMBO Journal·Leath A TonkinBrenda L Bass
Feb 17, 2000·Annals of the New York Academy of Sciences·T G GearyD P Thompson
May 25, 2005·Journal of Biomedical Optics·George FilippidisNektarios Tavernarakis
Jun 9, 2000·Annual Review of Neuroscience·A D Gibson, D L Garbers
Jul 19, 2005·Annual Review of Neuroscience·Mario de Bono, Andres Villu Maricq
Sep 11, 2010·Disease Models & Mechanisms·Trupti KawliMan-Wah Tan
Jun 11, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gareth HarrisRichard W Komuniecki
Oct 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wolfgang LiedtkeJeffrey M Friedman
Oct 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael Y ChaoAnne C Hart
Aug 28, 2003·Médecine sciences : M/S·Christelle Gally, Jean-Louis Bessereau
Sep 15, 2008·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·N J SzewczykM Viso
Jan 2, 2007·Seminars in Cancer Biology·Nikos Kourtis, Nektarios Tavernarakis
Jun 9, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Takaaki Hirotsu, Yuichi Iino
Dec 17, 2008·Annals of the New York Academy of Sciences·Wolfgang Liedtke
Aug 25, 2006·Headache·Miguel Estevez
Aug 25, 2015·Physiology & Behavior·S ShashikumarG K Rajanikant
Apr 5, 2014·The European Journal of Neuroscience·C Giovanni Galizia
Aug 6, 2005·Journal of Molecular Biology·Britta SpanierRalf Baumeister
Oct 16, 2012·Current Opinion in Neurobiology·Hiroyuki Sasakura, Ikue Mori
Apr 4, 2006·Developmental Biology·Caroline LacosteMadeleine Erard-Garcia

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
GTPase
two-hybrid

Software Mentioned

mec

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

BRAIN Initiative Cell Census Network (BICCN)

The BRAIN Initiative Cell Census Network aims to identify and provide experimental access to the different brain cell types to determine their roles in health and disease. Discover the latest research from researchers in the BRAIN Initiative Cell Census Network here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis