PMID: 8612336Nov 21, 1995Paper

Signal transduction mechanisms subserving activity-dependent release of neuronal proteoglycans

Brain Research. Developmental Brain Research
K Dow, M Sugiura

Abstract

We demonstrate here using dissociated hippocampal neurons that glutamate-induced release of proteoglycans which have been shown to have neurite growth-promoting activity is regulated by serine/threonine kinases of the protein kinase C and calcium/calmodulin type II kinase families, and that the state of phosphorylation of hippocampal neurons is a determinant of the magnitude and duration of the release response. Nitric oxide is also involved in mediating glutamate-induced PG release.

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Citations

Nov 22, 1996·Brain Research. Developmental Brain Research·B ChisamoreK Dow

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