PMID: 9440022Jan 24, 1998Paper

Signal transduction pathways and their relevance in human astrocytomas

Journal of Neuro-oncology
M M FeldkampA Guha

Abstract

Aberrations in a number of signal transduction pathways have been identified as playing a key role in the molecular pathogenesis of astrocytomas and their progression to high grade glioblastoma multiforme (GBM). GBMs are characterized by overexpression of the Platelet Derived Growth Factor Receptors (PDGFR) and their ligands (PDGF), as well as the Epidermal Growth Factor Receptor (EGF-R). These receptors activate the Ras pathway, a key cellular signal transduction pathway, culminating in the activation of a wide range of Ras-dependent cellular events. GBMs have also been found to either overexpression or lose expression of various Protein Kinase C (PKC) isoforms. Major strides are being made in developing pharmacological agents which specifically inhibit these growth factor receptors and intracellular signal transduction pathways. Elucidating the role of these pathways in GBMs is thus of major clinical importance, as these novel molecularly-targeted agents may prove of use in the clinical management of GBMs in the future.

Citations

Aug 17, 2002·Neurosurgery·Shaan M RazaRaymond Sawaya
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Edward W B JeffesMartin R Jadus
Apr 13, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Vasanth Kumar BhaskaraPhanithi Prakash Babu
Mar 24, 2006·Journal of Neuro-oncology·O KargiotisA P Kyritsis
Feb 26, 2009·Proteome Science·Paulo C CarvalhoValmir C Barbosa
Aug 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Diana Marcela MuñozCynthia Hawkins
Jan 30, 2013·Cancer Biology & Therapy·Anália do CarmoMaria Celeste Lopes
Mar 21, 2016·Current Protocols in Pharmacology·Fuyi ChenJoseph LoTurco
May 18, 1999·Current Opinion in Oncology·E Burton, M Prados
Apr 7, 2005·Glia·Patricia S RitchHarald Sontheimer
Oct 10, 2008·Acta Biotheoretica·M AubertB Grammaticos
Dec 3, 2010·The Tohoku Journal of Experimental Medicine·Dianhui TanRunlong Lai
Nov 30, 2018·International Journal of Molecular Sciences·Cristina Trejo-SolísJulio Sotelo
Dec 21, 2000·Current Oncology Reports·M P MehtaG H Olivera
Sep 4, 2003·The Cancer Journal·Stephen YipEvan Y Snyder
Aug 7, 2008·Neuro-oncology·Claire Marie-Elisabeth SauvageotPatrick Yung Chih Wen
Jan 18, 2006·Reviews in Medical Virology·Adam M SonabendMaciej S Lesniak
Jan 1, 2007·Expert Opinion on Drug Discovery·Sith SathornsumeteeJeremy N Rich
Dec 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·M Kelly NicholasRavi Salgia
Aug 18, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patrick Y WenMichael D Prados
Apr 21, 1999·Brain Research. Brain Research Reviews·M Bredel, I F Pollack
Jun 17, 2021·Molecular Biology Reports·M Janaki Ramaiah, K Rohil Kumar
Nov 30, 2004·Trends in Molecular Medicine·Andrew T Parsa, Eric C Holland
May 16, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Stephen YipEvan Y Snyder
Oct 30, 2007·Neurologic Clinics·Claire M SauvageotCharles D Stiles
Aug 17, 2010·Neuroimaging Clinics of North America·Eudocia C Quant, Patrick Y Wen

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