Signal transduction pathways in apoptosis

Stem Cells
D J McConkey, S Orrenius

Abstract

Emerging evidence indicates that apoptosis is regulated by some of the same signal transduction pathways previously implicated in other physiological cellular responses, including alterations in intracellular Ca2+ compartmentalization, activation of protein kinases and phosphatases, alteratios in pH and oxidative stress. Interestingly, signals that promote apoptosis in one model can suppress cell death in another, indicating that cellular responses are determined by the intrinsic programming of the cell in question. This review will summarize current knowledge of the signal transduction pathways regulating apoptosis and discuss how they may be coupled to components of the molecular machinery for cell death.

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R M Pratt, G R Martin
Jul 31, 1992·Biochemical and Biophysical Research Communications·M A Barry, A Eastman
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·F M UckunG L Schieven
Dec 1, 1992·The Journal of Cell Biology·C KosekiQ al-Awqati
Apr 3, 1992·Cell·G I EvanD C Hancock
Jan 1, 1990·The Prostate·P Martikainen, J Isaacs
Nov 15, 1990·Archives of Biochemistry and Biophysics·T Y AwS Orrenius
Apr 1, 1990·Biochemical Society Transactions·S V LennonT G Cotter
May 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D J McConkeyS Orrenius
Feb 15, 1989·Archives of Biochemistry and Biophysics·D J McConkeyS Orrenius
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·V DanielG M Tomkins
Nov 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·D V BasileA C Braun
Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Nov 9, 1995·Biochimica Et Biophysica Acta·W H Zhu, T T Loh
Dec 1, 1995·Experimental Cell Research·B ZhivotovskyS Orrenius
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·S YousefiH U Simon
Feb 1, 1995·The Journal of Experimental Medicine·F VignauxP Golstein
Apr 27, 1995·Nature·M D Jacobson, M C Raff
May 1, 1995·Experimental Cell Research·D AharoniA Amsterdam
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·R A GottliebB M Babior
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·C G TepperM F Seldin
Sep 22, 1995·The Journal of Biological Chemistry·A J McGahonD R Green
Sep 25, 1995·Biochemical and Biophysical Research Communications·Q P DouC Yu
Nov 10, 1995·The Journal of Biological Chemistry·H SawaiH Umehara
Apr 1, 1995·Molecular Biology of the Cell·G J Den HaeseK L Gould

❮ Previous
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Citations

Oct 16, 1999·International Journal of Cancer. Journal International Du Cancer·K HocheggerB Marian
Mar 10, 2001·Molecular Reproduction and Development·W J Murdoch, E A Van Kirk
Jul 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H C Pitot
Sep 10, 2005·Apoptosis : an International Journal on Programmed Cell Death·C Udawatte, H Ripps
Apr 7, 2007·Cancer Metastasis Reviews·Pawel SwietachAdrian L Harris
Jan 21, 2000·Brain Research·A A dos Santos, E G de Araujo
Feb 17, 1999·Prostaglandins & Other Lipid Mediators·J E VierkW J Murdoch
Apr 7, 2000·Brain Research. Brain Research Reviews·R Linden
Dec 23, 1998·Toxicology Letters·D J McConkey
Oct 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M I Pörn-AresS Orrenius
May 12, 1998·Surgical Oncology·R J BoldD J McConkey
Nov 10, 2006·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·D W Voehringer, R E Meyn
Feb 29, 2000·Eye·J WuE Chen
Jun 19, 1998·Neuroreport·H S MogensenO S Jorgensen
May 26, 1998·Annals of the New York Academy of Sciences·M J DeLong
Mar 15, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Erika C ClaudTamas Jilling
Nov 26, 1999·American Journal of Respiratory Cell and Molecular Biology·H Y Zhang, S H Phan
Feb 5, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Pawel SwietachAlzbeta Hulikova
Feb 24, 2001·American Journal of Veterinary Research·L A CuddK D Clinkenbeard
Apr 20, 2010·Mutation Research·Aneta RogalskaZofia Jóźwiak
May 1, 2007·European Journal of Pharmacology·Margarita Ramirez-OrtegaGustavo Pastelin
Aug 23, 2005·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Jai ParkashWilliam B Rhoten
Mar 22, 2005·British Journal of Pharmacology·Roberto Gabriel PoznerMirta Schattner
Apr 28, 2012·Journal of Biomedical Materials Research. Part a·Margaret A WheatleyKelleny L Oum
Sep 4, 2015·Molecular Carcinogenesis·Erika Contreras-LealJuan Santiago-García
Feb 29, 2008·BMB Reports·Song Iy HanTae-Hyoung Kim
Aug 11, 2000·Seminars in Cancer Biology·S Kanzler, P R Galle
Apr 2, 1998·Experimental Cell Research·M Marini, D Musiani
Nov 5, 1997·Biochemical and Biophysical Research Communications·D J McConkey, S Orrenius
Nov 6, 2014·Molecular Medicine Reports·Wenping DingSiyu Chen

❮ Previous
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