Signal transduction pathways involved in interaction of galactosylceramide/sulfatide-containing liposomes with cultured oligodendrocytes and requirement for myelin basic protein and glycosphingolipids

Journal of Neuroscience Research
Joan M BoggsYukie Hirahara

Abstract

We showed previously that the addition to cultured oligodendrocytes (OLs) of multivalent carbohydrate in the form of liposomes containing the two major glycosphingolipids (GSLs) of myelin, galactosylceramide (GalC) and cerebroside sulfate (Sulf), or galactose conjugated to bovine serum albumin caused clustering of GalC on the extracellular surface and myelin basic protein (MBP) on the cytosolic surface. Multivalent carbohydrate also caused depolymerization of actin microfilaments and microtubules, indicating that interaction of the carbohydrate with the OL surface transmits a transmembrane signal to the cytoskeleton. In the present study we show that inhibition of GSL synthesis with fumonisin B1 prevents clustering of MBP in GalC/Sulf-negative oligodendrocytes, suggesting that GSLs are required for the effect. Because the effects of multivalent carbohydrate resemble those caused by the addition of anti-GalC/Sulf antibodies to OLs and because GalC and Sulf can interact with each other by trans carbohydrate-carbohydrate interactions across apposed membranes, these results support the conclusion that the OL receptor for GalC/Sulf in liposomes is GalC/Sulf in the OL membrane. Inhibition of MBP expression using MBP siRNA inhibited G...Continue Reading

References

Feb 19, 1990·Biochimica Et Biophysica Acta·R H van der PalM Lopes-Cardozo
Jan 1, 1990·Annals of the New York Academy of Sciences·J A Benjamins, C A Dyer
Aug 1, 1986·Biochimica Et Biophysica Acta·J W KoperM Lopes-Cardozo
Mar 1, 1994·Journal of Neurochemistry·J KarthigasanD A Kirschner
Dec 22, 1999·The Journal of Cell Biology·J L DupreeB Popko
Feb 5, 2000·Journal of Neuroscience Research·C Richter-Landsberg
Nov 18, 2000·Experimental Cell Research·M AmanoK Kaibuchi
Dec 1, 2001·Progress in Neurobiology·S D SkaperF S Walsh
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sen-itiroh Hakomori Si
Mar 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Koichi HonkeNaoyuki Taniguchi
Jun 18, 2002·Journal of Neurochemistry·Christopher M TaylorSteven E Pfeiffer
Jun 19, 2002·Biochimica Et Biophysica Acta·C L SayasF Wandosell
Jan 22, 2003·The Biochemical Journal·Jenny BainPhilip Cohen
Aug 21, 2003·The Journal of Biological Chemistry·Ratan BhatJesús Avila
Dec 23, 2003·Journal of Neuroscience Research·F D TestaiG Dawson

❮ Previous
Next ❯

Citations

Nov 15, 2011·Neurochemistry International·Catherine FressinaudJoël Eyer
Dec 17, 2008·Biochimica Et Biophysica Acta·Bodil Westerlund, J Peter Slotte
May 21, 2009·Glia·Nina G BauerCharles Ffrench-Constant
May 23, 2012·Biochemical and Biophysical Research Communications·Graham S T SmithGeorge Harauz
Jun 26, 2012·Biochimica Et Biophysica Acta·Daniel R KattnigDariush Hinderberger
Aug 9, 2011·Biochimica Et Biophysica Acta·Ruba AlajlouniDaniel G S Capelluto
Feb 14, 2015·Biochimica Et Biophysica Acta·Massimo AureliAlessandro Prinetti
Mar 19, 2013·International Journal of Biological Macromolecules·Cinzia Di SalvoErsilia Bellocco
Sep 13, 2011·Angewandte Chemie·Timothy M AltamoreTimothy Gallagher
Feb 23, 2020·Histochemistry and Cell Biology·Takashi HashimotoKen-Ichi Matsuda
Feb 13, 2013·Journal of Neurochemistry·George Harauz, Joan M Boggs
Apr 5, 2013·Chemical Communications : Chem Comm·Harikrishna BavireddiRaghavendra Kikkeri
Aug 9, 2011·Biosensors & Bioelectronics·Jian Zhang, Xichun Zhou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.