Signal transduction pathways leading to cell cycle arrest and apoptosis induced by DNA topoisomerase poisons

Cell Biochemistry and Biophysics
T Andoh

Abstract

In this overview, I have summarized the important pathways of stress-induced signal transduction: stabilization and activation of p53 playing a central role in stress-induced cell cycle checkpoint and apoptosis, and activation of ASK1-JNK/p38 pathway often induced by a variety of stress stimuli, which appears to be essentially required for apoptosis to follow.

Citations

Dec 17, 2002·Critical Reviews in Oncology/hematology·Christian Bailly
Feb 6, 2013·The Journal of Biological Chemistry·Zhiyou Fang, Elizabeth J Luna
May 18, 2013·Vascular Pharmacology·R PescadorM E Ferrero
Nov 1, 2002·The Journal of Biological Chemistry·Rafael RamírezMaría A Blasco
Feb 8, 2002·American Journal of Physiology. Cell Physiology·James R TrimarchiDavid L Keefe
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tiziana ToniniAntonio Giordano

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