Signaling and induction of chaperone-mediated autophagy by the endoplasmic reticulum under stress conditions

Autophagy
Wenming LiZixu Mao

Abstract

Chaperone-mediated autophagy (CMA), a form of selective autophagy, maintains cellular proteostasis in response to diverse stress conditions. Whether and how endoplasmic reticulum (ER) stress triggers CMA remains elusive. In our recent study, we demonstrate that various types of ER stress activate the CMA pathway via an EIF2AK3/PERK-MAP2K4/MKK4-MAPK14/p38-dependent manner. We term this process ERICA for ER stress-induced chaperone-mediated autophagy. This pathway is activated in response to stress associated with Parkinson disease and is required for the viability of the SNc dopaminergic neurons in an animal model of Parkinson disease.

Citations

Jan 8, 2019·Human Molecular Genetics·Gali MaorMia Horowitz
Feb 12, 2020·Medicinal Research Reviews·Vibhuti JoshiAmit Mishra
Jul 24, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yusuke HosakaKazuyoshi Kuwano
Mar 27, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Zhuang QianShufang Wu
Feb 16, 2019·Frontiers in Endocrinology·Iván E AlfaroMauricio Budini
Jul 8, 2020·Mechanisms of Ageing and Development·Shahrzad TalebianMohammad Reza Alivand
May 6, 2021·Biochemical and Biophysical Research Communications·Akira KitamuraMasataka Kinjo

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Methods Mentioned

BETA
immunoprecipitation

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