Signaling at the Crossroads: Matrix-Derived Proteoglycan and Reactive Oxygen Species Signaling

Antioxidants & Redox Signaling
Madalina-Viviana NastaseLiliana Schaefer

Abstract

Proteoglycans (PGs), besides their structural contribution, have emerged as dynamic components that mediate a multitude of cellular events. The various roles of PGs are attributed to their structure, spatial localization, and ability to act as ligands and receptors. Reactive oxygen species (ROS) are small mediators that are generated in physiological and pathological conditions. Besides their reactivity and ability to induce oxidative stress, a growing body of data suggests that ROS signaling is more relevant than direct radical damage in development of human pathologies. Recent Advances: Cell surface transmembrane PGs (syndecans, cluster of differentiation 44) represent receptors in diverse and complex transduction networks, which involve redox signaling with implications in cancer, fibrosis, renal dysfunction, or Alzheimer's disease. Through NADPH oxidase (NOX)-dependent ROS, the extracellular PG, hyaluronan is involved in osteoclastogenesis and cancer. The ROS sources, NOX1 and NOX4, increase biglycan-induced inflammation, while NOX2 is a negative regulator. The complexity of the mechanisms that bring ROS into the light of PG biology might be the foundation of a new research area with significant promise for understanding he...Continue Reading

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Citations

Jan 2, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Madalina V NastaseLiliana Schaefer
Jan 2, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Charles W FrevertLiliana Schaefer
Aug 11, 2017·Antioxidants & Redox Signaling·David D Roberts
Jul 18, 2017·Antioxidants & Redox Signaling·David D RobertsJeffrey S Isenberg
Apr 12, 2019·The FEBS Journal·Alberto PassiRenato V Iozzo
Jul 7, 2020·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jinyang Zeng-BrouwersLiliana Schaefer
Sep 14, 2018·Frontiers in Cell and Developmental Biology·Zhe WangMargot Zöller
May 10, 2019·Frontiers in Immunology·George TzanakakisDragana Nikitovic
Jan 11, 2020·Frontiers in Oncology·Wei MuMargot Zöller
Apr 29, 2019·Cancer Metastasis Reviews·Zhe Wang, Margot Zöller
Nov 8, 2020·Cell Death & Disease·José-Manuel Rodriguez-VargasFrançoise Dantzer
Mar 4, 2021·Reviews in the Neurosciences·Jia-Zhe LinWei-Jiang Zhao

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Methods Mentioned

BETA
GTPase

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