Signaling in malignant astrocytomas: role of neural stem cells and its therapeutic implications.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Sheila Alcantara LlagunoLuis F Parada

Abstract

Malignant astrocytomas are infiltrative and aggressive brain tumors. Conventional forms of therapy have not been effective in controlling this incurable disease. Recent advances in understanding the molecular biology of these tumors have revealed potential mechanisms by which astrocytoma cells undergo tumor initiation, progression, and maintenance, as well as possible avenues for targeted therapeutics. Studies on the role of neural stem cells as cells of origin and tumor-propagating cells have also greatly increased our understanding of the biology and clinical behavior of these tumors. An integrated view of the genetics, signal transduction, and cell biology of astrocytomas, as well as clinical data from patients, will provide a more useful approach in designing novel therapies for this devastating disease.

References

Mar 21, 1998·Science·Z G WangP P Pandolfi
Feb 26, 2000·Science·F H Gage
Jun 8, 2001·Genes & Development·E A MaherR A DePinho
Aug 3, 2002·Nature Reviews. Cancer·Yuan Zhu, Luis F Parada
Dec 7, 2002·Nature Neuroscience·Karen LaiDavid V Schaffer
May 12, 2004·Nature Reviews. Drug Discovery·Jeremy N Rich, Darell D Bigner
Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jun 10, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Biplab Dasgupta, David H Gutmann
Aug 27, 2005·The New England Journal of Medicine·Nader SanaiMitchel S Berger
Oct 28, 2005·Nature·Dieter-Chichung LieFred H Gage
Dec 22, 2005·Development·Konstantinos MeletisJonas Frisén
Dec 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Matthias GroszerHong Wu
Jan 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sara Gil-PerotinPatricia Casaccia-Bonnefil
Jun 27, 2006·Nature·Andreas Androutsellis-TheotokisRonald D G McKay
Sep 26, 2006·Nature Medicine·Liqing JinJohn E Dick
Jan 2, 2007·Current Biology : CB·Virginie ClementAriel Ruiz i Altaba
Jul 21, 2007·Science·Priscilla N KellyAndreas Strasser
Oct 30, 2007·Neurologic Clinics·Robert CavaliereDavid Schiff
Nov 3, 2007·Genes & Development·Frank B FurnariWebster K Cavenee
Nov 28, 2007·Annual Review of Pathology·David N Louis
Feb 26, 2008·Cell·Chunmei ZhaoFred H Gage
Feb 26, 2008·Nature Neuroscience·Young-Goo HanArturo Alvarez-Buylla
May 3, 2008·Cancer Research·Chang-Hyuk KwonLuis F Parada
Jul 17, 2008·Nature Clinical Practice. Neurology·Sunit DasJohn A Kessler
Sep 6, 2008·Science·D Williams ParsonsKenneth W Kinzler
Sep 6, 2008·Nature·UNKNOWN Cancer Genome Atlas Research Network
Oct 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·M Yashar S KalaniRoel Nusse
Nov 8, 2008·Annals of the New York Academy of Sciences·Sith Sathornsumetee, Jeremy N Rich
Dec 5, 2008·Nature·Elsa QuintanaSean J Morrison

❮ Previous
Next ❯

Citations

Sep 3, 2013·Cell Death and Differentiation·A DickinsonJ C St John
Jun 25, 2010·Nature Reviews. Cancer·Joerg HeyerLynda Chin
Apr 6, 2011·The Journal of Experimental Medicine·Sameer AgnihotriAbhijit Guha
Jan 30, 2013·Carcinogenesis·Xiao-Han TangLorraine J Gudas
Mar 18, 2010·Cancer Research·Xiwei WuGerd P Pfeifer
Jun 15, 2004·Journal of Translational Medicine·Ester Fonsatti, Michele Maio
Oct 26, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Albert LaiHeidi S Phillips
Jul 25, 2014·Cellular and Molecular Neurobiology·Vishal RajagopalanJames E Bradner
Jul 15, 2011·Stem Cell Reviews and Reports·Ji-Seon LeeHyuk Jin Cha
Jun 21, 2011·Brain Research Bulletin·Ralf S SchmidC Ryan Miller
Jul 7, 2015·Cell Reports·Joshua J BreunigMoise Danielpour
Jul 26, 2011·Annals of Neurology·Matthias PreusserRoger Stupp
May 21, 2016·Frontiers in Immunology·Aleli Salazar-RamiroBenjamín Pineda
Apr 26, 2012·Molecular Cancer Therapeutics·Shinji KohsakaShinya Tanaka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.