PMID: 7516664Apr 1, 1994Paper

Signaling mechanisms in thymocyte selection

Current Opinion in Immunology
E V Rothenberg

Abstract

The processes known as positive and negative selection that determine the fate of T and B cells depend on finely tuned interactions between the T-cell receptor complex, CD4 or CD8 co-receptors, and a peptide-MHC complex. New work indicates that the avidity of this interaction is critical in the determination of its outcome. The effects of these interactions on developing thymocytes are also a function of the unique activation properties with which thymocytes are programmed just before they undergo selection.

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