Signaling mechanisms underlying group I mGluR-induced persistent AHP suppression in CA3 hippocampal neurons

Journal of Neurophysiology
Steven R YoungRobert K S Wong

Abstract

Activation of group I metabotropic glutamate receptors (mGluRs) leads to a concerted modulation of spike afterpotentials in guinea pig hippocampal neurons including a suppression of both medium and slow afterhyperpolarizations (AHPs). Suppression of AHPs may be long-lasting, in that it persists after washout of the agonist. Here, we show that persistent AHP suppression differs from short-term, transient suppression in that distinct and additional signaling processes are required to render the suppression persistent. Persistent AHP suppression followed DHPG application for 30 min, but not DHPG application for 5 min. Persistent AHP suppression was temperature dependent, occurring at 30-31 degrees C, but not at 25-26 degrees C. Preincubation of slices in inhibitors of protein synthesis (cycloheximide or anisomycin) prevented the persistent suppression of AHPs by DHPG. Similarly, preincubation of slices in an inhibitor of p38 MAP kinase (SB 203580) prevented persistent AHP suppression. In contrast, a blocker of p42/44 MAP kinase activation (PD 98059) had no effect on persistent AHP suppression. Additionally, we show that the mGluR5 antagonist MPEP, but not the mGluR1 antagonist LY 367385, prevented DHPG-induced persistent AHP suppr...Continue Reading

References

Jan 1, 1990·Progress in Brain Research·J F Storm
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·D T DudleyA R Saltiel
Feb 12, 1999·Brain Research. Brain Research Reviews·R Anwyl
Jul 8, 1999·Current Opinion in Neurobiology·Z A BortolottoG L Collingridge
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·E C CooperL Y Jan
Jan 30, 2002·Brain Research·Huiqing LiJun-Ming Zhang
May 17, 2002·The Journal of Physiology·Shih-Chieh ChuangRobert K S Wong
Jul 2, 2002·Journal of Neurophysiology·David R Ireland, Wickliffe C Abraham
Oct 5, 2002·Journal of Neurophysiology·Angela C LeeRiccardo Bianchi
Jun 20, 2003·Journal of Neurophysiology·M Matthew OhJohn F Disterhoft
Nov 5, 2003·Nature Reviews. Neuroscience·Wei Zhang, David J Linden
Dec 23, 2003·The European Journal of Neuroscience·Fivos VogalisBarrie Lancaster
Jan 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wangfa ZhaoRobert K S Wong
May 21, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sean M GallagherKimberly M Huber
Nov 20, 2004·Nature Reviews. Neuroscience·Eric Klann, Thomas E Dever
Jun 17, 2005·Cerebral Cortex·Itay ZelcerEdi Barkai
Sep 2, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shih-Chieh ChuangRobert K S Wong
Feb 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessica L BankoEric Klann
Apr 25, 2006·The European Journal of Neuroscience·Masuo OhnoJohn F Disterhoft

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Citations

Aug 14, 2010·Cerebral Cortex·Darah E Fontanez-NuinJames T Porter
Feb 9, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steven R YoungRiccardo Bianchi
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Riccardo BianchiRobert K S Wong
Feb 24, 2015·Brain Research·William C Buchta, Arthur C Riegel
Jan 24, 2018·Neural Plasticity·Geehoon Chung, Sang Jeong Kim
Jan 10, 2020·Neuroscience·Ernesto Griego, Emilio J Galván
Apr 2, 2021·ELife·Laura E MaglioDavid Fernández de Sevilla

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