Signaling pathways for B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) in human placenta.

The American Journal of Pathology
Daudi L LangatJoan S Hunt

Abstract

The tumor necrosis superfamily (TNFSF) contains two soluble ligands that are involved in B lymphocyte development, BAFF (B cell activating factor, BlyS, TALL-1, CD257, TNFSF13B) and APRIL (a proliferation inducing ligand, CD256, TNFSF13). These two ligands signal through three receptors: the exclusive BAFF receptor (BAFF-R, CD268, TNFRSF17) and two receptors that recognize both BAFF and APRIL, TACI (transmembrane-activator-1 and calcium-modulator- and cyclophilin ligand-interactor CD267, TNFRSF13B) and BCMA (B cell maturation antigen, CD269, TNFRSF13C). All but BAFF-R are known to be synthesized in term placentas. In this study, expression of the ligands and receptors were distinguished in two embryologically discrete subpopulations of placental cells, villous cytotrophoblast (vCTB) cells and mesenchymal cells (MCs). Real-Time PCR showed that vCTB cells contain low levels of BAFF and APRIL transcripts whereas MCs contain high levels. Both Real-Time PCR and immunohistochemistry identified BAFF-R and BCMA mRNA and proteins in vCTB cells but essentially no TACI. By contrast, MCs contained readily detectable levels of all three receptors. These results illustrating potential autocrine and paracrine pathways for BAFF and APRIL signa...Continue Reading

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Citations

Jan 30, 2013·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Xin-Pu GaoYue-Ran Zhao
May 21, 2013·Cytokine & Growth Factor Reviews·Fabien B VincentFabienne Mackay
Apr 13, 2011·PloS One·Apostolos ZaravinosDemetrios A Spandidos
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Sep 23, 2016·Digestive Diseases and Sciences·Mathieu UzzanSaurabh Mehandru
Jan 7, 2017·Scientific Reports·Anna-Carin LundellAnna Rudin
Jan 10, 2019·American Journal of Reproductive Immunology : AJRI·Jorge LimaMaria Leandro
Jun 13, 2009·Nature Reviews. Immunology·Fabienne Mackay, Pascal Schneider
Oct 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·George NotasElias Castanas
Jun 27, 2012·Molecular Endocrinology·Bingbing WangTodd Rosen
Aug 6, 2020·Cancers·Adam UtleyMikhail A Nikiforov
Mar 9, 2021·American Journal of Reproductive Immunology : AJRI·Catarina MartinsLuís Miguel Borrego
Jun 29, 2021·Current Opinion in Immunology·Mahya Eslami, Pascal Schneider

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