Signaling pathways in aged T cells - a reflection of T cell differentiation, cell senescence and host environment.

Seminars in Immunology
J J GoronzyC M Weyand

Abstract

With increasing age, the ability of the immune system to protect against new antigenic challenges or to control chronic infections erodes. Decline in thymic function and cumulating antigenic experiences of acute and chronic infections threaten T cell homeostasis, but insufficiently explain the failing immune competence and the increased susceptibility for autoimmunity. Alterations in signaling pathways in the aging T cells account for many of the age-related defects. Signaling threshold calibrations seen with aging frequently built on mechanisms that are operational in T cell development and T cell differentiation or are adaptations to the changing environment in the aging host. Age-related changes in transcription of receptors and signaling molecules shift the balance towards inhibitory pathways, most dominantly seen in CD8 T cells and to a lesser degree in CD4 T cells. Prominent examples are the expression of negative regulatory receptors of the CD28 and the TNF receptor superfamilies as well the expression of various cytoplasmic and nuclear dual-specific phosphatases.

References

May 5, 1997·The Journal of Experimental Medicine·A P CopeH O McDevitt
Feb 17, 1998·Developmental and Comparative Immunology·R B Effros
Feb 26, 1998·Immunological Reviews·R A MillerJ M Witkowski
Jun 10, 1998·Cytokine & Growth Factor Reviews·T HiranoM Hibi
Aug 4, 1998·The Journal of Experimental Medicine·D D BilladeauP J Leibson
Mar 11, 1999·Journal of Receptor and Signal Transduction Research·M H Heim
May 8, 2001·Experimental and Clinical Immunogenetics·C BrenderN Ødum
Sep 13, 2001·Stem Cells·D L Krebs, D J Hilton
Jan 5, 2002·Molecular and Cellular Biology·Sonja I GringhuisCornelis L Verweij
Dec 18, 2002·Annals of the New York Academy of Sciences·Tamas FulopGilles Dupuis
Jan 9, 2003·JAMA : the Journal of the American Medical Association·William W ThompsonKeiji Fukuda
Mar 21, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Lykke Larsen, Carsten Röpke
Jun 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Christoph WulfingJohn D Schatzle
Aug 15, 2003·Molecular and Cellular Biology·Christopher C StebbinsEric O Long
Nov 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jordan S OrangeJack L Strominger
Nov 25, 2003·European Journal of Immunology·Gonzalo G Garcia, Richard A Miller
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Joanna M ClarkAndrew P Cope
May 8, 2004·Experimental Gerontology·Karen Suárez KrabbeHelle Bruunsgaard
May 12, 2004·Current Opinion in Immunology·Paul J Leibson
Sep 3, 2004·Nature Reviews. Immunology·Arne N AkbarMike Salmon
Sep 29, 2004·Free Radical Biology & Medicine·Mark S Williams, Jaeyul Kwon
Jan 26, 2005·European Journal of Immunology·Gonzalo G GarciaRichard A Miller
Mar 1, 2005·Cell·Robert S BalabanToren Finkel
Jun 3, 2005·The New England Journal of Medicine·Ann Arvin
Aug 3, 2005·Current Opinion in Immunology·Amir A Sadighi Akha, Richard A Miller
Aug 16, 2005·Current Opinion in Immunology·Arne N Akbar, Jean M Fletcher
Mar 15, 2006·Mechanisms of Ageing and Development·T FulopG Herbein
Jul 11, 2006·Annual Review of Genetics·Karel RihaDorothy E Shippen
Jul 20, 2006·The Journal of Biological Chemistry·Stephen P BerasiRobert V Martinez
Jan 16, 2007·Experimental Gerontology·Jörg J GoronzyCornelia M Weyand
Mar 9, 2007·Genes & Development·Joel R NeilsonPhillip A Sharp
Apr 27, 2007·Annals of the New York Academy of Sciences·Andru TomoiuTamas Fulop
Aug 23, 2007·Nature Reviews. Molecular Cell Biology·D Grahame Hardie
Aug 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ariel QuintanaMarkus Hoth

❮ Previous
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Citations

Nov 22, 2013·Autoimmune Diseases·Gladis Montoya-Ortiz
Mar 26, 2014·Immunobiology·Michael BadowskiDavid T Harris
Jun 18, 2014·Current Opinion in Immunology·Tamas FulopAnis Larbi
Mar 5, 2013·The Journal of Clinical Investigation·Encarnacion Montecino-RodriguezKenneth Dorshkind
Apr 20, 2013·Nature Immunology·Jörg J Goronzy, Cornelia M Weyand
Jun 25, 2015·Journal of Clinical and Experimental Hematopathology : JCEH·Thien Phu TruongShigeru Chiba
Sep 26, 2015·Human Vaccines & Immunotherapeutics·Ho NamkoongNaoki Hasegawa
Mar 16, 2016·Nature Reviews. Clinical Oncology·Danny N KhalilJedd D Wolchok
Aug 6, 2014·Immunology·Bart-Jan KroesenJoost Kluiver
Jun 20, 2015·Frontiers in Neuroscience·Michela DeleidiGraziella Rubino
Feb 14, 2015·Ageing Research Reviews·Ludmila Müller, Graham Pawelec
Mar 4, 2015·Blood·Alexandre BignonKarl Balabanian
Jan 1, 2014·Mechanisms of Ageing and Development·Mònica MaijóSimon R Carding
May 7, 2016·European Journal of Immunology·Yair BotbolFernando Macian
Jul 2, 2016·Clinical and Experimental Immunology·T FulopA Larbi
Sep 7, 2016·European Journal of Immunology·Marcello PintiAndrea Cossarizza
Dec 23, 2016·Annals of the American Thoracic Society·Cornelia M Weyand, Jörg J Goronzy
Apr 19, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jörg J GoronzyCornelia M Weyand
May 21, 2019·Transplantation·Yeqi NianStefan G Tullius
Oct 23, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Megan J SmitheyJanko Nikolich-Žugich
Mar 16, 2017·Frontiers in Medicine·Silvia MartínCesar Aldecoa
Dec 10, 2016·Frontiers in Immunology·Joshua J MichelAbbe N Vallejo
Oct 16, 2018·Frontiers in Immunology·Gu-Lung LinAndrew J Pollard
Feb 23, 2019·Cellular and Molecular Life Sciences : CMLS·Antero SalminenAnu Kauppinen
May 14, 2020·Cells·Weili XuAnis Larbi
Sep 7, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Janko Nikolich-Žugich
Dec 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristin R RenkemaJanko Nikolich-Žugich
Dec 4, 2013·Current Opinion in Rheumatology·Cornelia M WeyandJörg J Goronzy
Jul 22, 2017·The Cancer Journal·Kristen A Marrone, Patrick M Forde
Jul 31, 2020·Nature Reviews. Immunology·Zeyu Chen, E John Wherry
Nov 22, 2016·Frontiers in Immunology·Branca I Pereira, Arne N Akbar
Aug 28, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bojana Müller-DurovicArne N Akbar
Mar 8, 2017·Journal of Clinical Periodontology·Philip M PreshawGeorg Conrads
Sep 16, 2020·Seminars in Immunopathology·T FulopJ M Witkowski
Dec 3, 2020·Frontiers in Immunology·Marina Andrade BatistaAna Maria Caetano Faria
Mar 9, 2021·Frontiers in Immunology·Stefania CuzzubboStephanie E B McArdle

❮ Previous
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