Jun 9, 2010

Signaling pathways in T follicular helper cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Julia RolfMartin Turner

Abstract

Th cell functional subsets have unique transcriptional programs that form the molecular basis for T cell differentiation and functions. T follicular helper (TFH) cells have emerged as the main providers of T cell help to B cells during the germinal center (GC) reaction, where B cells undergo selection events through competition for Ag and for access to GC T cell-mediated prosurvival and differentiation signals. Because T cell help is one limiting factor for GC B cells, the molecular mechanisms controlling TFH cell abundance and functionality are central to the GC reaction and generation of long-term humoral immunity. Two signaling pathways are absolutely critical for TFH cells: phosphoinositide-3 kinase pathway and the signaling lymphocyte activation molecule-associated protein. In this review, the molecular mechanisms constituting the signaling network in TFH cells will be explored.

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Mentioned in this Paper

Metabolic Process, Cellular
VAV1 gene
Biochemical Pathway
FOXO1 gene
ICOSLG gene
Phosphatidylinositols
T-Lymphocyte
IL17C gene
Structure of Germinal Center of Lymph Node
SLAMF6 wt Allele

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