Abstract
Exogenously administered chemically modified apelin-12 (MA) has been shown to exhibit protective effects in myocardial ischemia/reperfusion (I/R) injury. They include reduction of ROS formation, cell death and cardiometabolic abnormalities. The aim of the present study was to explore the role of the underlying signaling mechanisms involved in cardioprotection afforded by MA. Isolated perfused working rat hearts subjected to global ischemia and anaesthetized rats in vivo exposed to LAD coronary artery occlusion were used. Myocardial infarct size, cell membrane damage, cardiac dysfunction and metabolic state of the heart were used as indices of I/R injury at the end of reperfusion. Administration of specific inhibitors of MEK1/2, PI3K, NO synthase (NOS) or the mitochondrial ATP-sensitive K(+) (mito KATP) channels (UO126, LY294002, L-NAME or 5-hydroxydecanoate, respectively) reduced protective efficacy of MA in both models of I/R injury. This was evidenced by abrogation of infarct size limitation, deterioration of cardiac function recovery, and attenuation of metabolic restoration and sarcolemmal integrity. An enhancement of functional and metabolic recovery in isolated reperfused hearts treated with MA was suppressed by U-73122, ...Continue Reading
References
May 1, 1996·Journal of Molecular and Cellular Cardiology·A C Cave, C S Apstein
Oct 16, 1999·Circulation Research·J C Kentish
Oct 26, 1999·Circulation Research·M KarmazynK Kusumoto
Jan 30, 2002·The Journal of Biological Chemistry·Chad VickersPeter Tummino
Sep 7, 2002·Circulation Research·István SzokodiHeikki Ruskoaho
Dec 18, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ken ShinmuraRoberto Bolli
May 24, 2005·Pharmacology & Therapeutics·Matthias J Kleinz, Anthony P Davenport
Feb 2, 2006·Basic Research in Cardiology·Claudia PennaPasquale Pagliaro
Aug 8, 2007·Pharmacology & Therapeutics·Derek J Hausenloy, Derek M Yellon
Aug 19, 2007·Basic Research in Cardiology·James C SimpkinChristopher C T Smith
Aug 28, 2007·Peptides·Yue Xia JiaYong Fen Qi
Nov 21, 2007·Regulatory Peptides·Matthias J Kleinz, Gary F Baxter
Nov 18, 2008·Biochimica Et Biophysica Acta·Michael J Berridge
May 26, 2009·Peptides·Xiang Jun ZengChao Shu Tang
Jul 4, 2009·Circulation Research·Cristina D'AnielloGabriella Minchiotti
Dec 31, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xavier IturriozCatherine Llorens-Cortes
Apr 14, 2010·Circulation·A G JappD E Newby
Jul 8, 2010·Pharmacological Reviews·Sarah L PitkinAnthony P Davenport
Oct 6, 2010·Pharmacology & Therapeutics·Christopher C T Smith, Derek M Yellon
Mar 8, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Raffaella RastaldoPasquale Pagliaro
Aug 2, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Jianping TaoMeng Wei
Jul 17, 2012·Bioorganicheskaia khimiia·M V SidorovaZh D Bespalova
Sep 19, 2012·Peptides·Z Q JiaG Y Akita
Jun 4, 2013·Peptides·Yaser AziziAfshin Nazari
Aug 21, 2013·Journal of Pharmacology & Pharmacotherapeutics·Oleg I PisarenkoAlexander S Molokoedov
Sep 24, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiao-Hua YuChao-Ke Tang
Dec 19, 2014·British Journal of Pharmacology·Oleg PisarenkoOksana Kunduzova
Citations
Nov 18, 2016·DNA and Cell Biology·Zhe ChenLinxi Chen
Feb 22, 2018·Journal of Physiology and Biochemistry·Irina StudnevaOleg Pisarenko
Feb 9, 2017·Oncotarget·Andrei TimotinOksana Kunduzova
Sep 25, 2020·Cells·Alessandro BellisCarmine Morisco
Sep 8, 2019·Pharmacological Reviews·Cai ReadAnthony P Davenport
Jul 28, 2017·Acta Physiologica·A FolinoR Rastaldo
Jun 8, 2018·Frontiers in Physiology·Marta B WysockaDorota Nowak
Jul 28, 2019·Current Medical Science·Xu-Chu PanYong-Tang Song
Feb 15, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Maryam Eskandari MehrabadiSaman Hosseinkhani