Abstract
The F11 receptor (F11R) (a.k.a. Junctional Adhesion Molecule, JAM) was first identified in human platelets as a 32/35 kDa protein duplex that serves as receptor for a functional monoclonal antibody that activates platelets. We have sequenced and cloned the F11R and determined that it is a member of the immunoglobulin (Ig) superfamily of cell adhesion molecules. The signaling pathways involved in F11R-induced platelet activation were examined in this investigation. The binding of M.Ab.F11 to the platelet F11R resulted in granule secretion and aggregation. These processes were found to be dependent on the crosslinking of F11R with the Fc gammaRII by M.Ab.F11. This crosslinking induced actin filament assembly with the conversion of discoidal platelets to activated shapes, leading to the formation of platelet aggregates. We demonstrate that platelet secretion and aggregation through the F11R involves actin filament assembly that is dependent on phosphoinositide-3 kinase activation, and inhibitable by wortmannin. Furthermore, such activation results in an increase in the level of free intracellular calcium, phosphorylation of the 32 and 35 kDa forms of the F11R, F11R dimerization coincident with a decrease in monomeric F11R, and ass...Continue Reading
References
Sep 1, 1992·The Journal of Cell Biology·J H Hartwig
Jun 1, 1989·Trends in Pharmacological Sciences·U T Rüegg, G M Burgess
Jan 1, 1987·Advances in Experimental Medicine and Biology·D R SibleyR J Lefkowitz
May 1, 1987·The Journal of Antibiotics·H NakanoH Iba
Jan 15, 1988·The Biochemical Journal·S P WatsonP P Godfrey
Mar 13, 1986·Biochemical and Biophysical Research Communications·T TamaokiF Tomita
Oct 15, 1986·Thrombosis Research·A YamaguchiH Yamazaki
Sep 1, 1985·The Journal of Cell Biology·T H Howard, C O Oresajo
Jan 1, 1985·Cell Motility·T H Howard, C O Oresajo
Nov 1, 1984·Archives of Biochemistry and Biophysics·D T PangJ A Shafer
Oct 15, 1995·The Biochemical Journal·F WangE Kornecki
Aug 15, 1995·The Biochemical Journal·U P NaikE Kornecki
Dec 20, 1996·The Journal of Biological Chemistry·J H HartwigA Toker
Feb 15, 1997·European Journal of Biochemistry·J R SlupskyM Zuzel
Nov 14, 1997·The Biochemical Journal·F E IndigM H Ginsberg
Jul 14, 1998·The Journal of Cell Biology·I Martìn-PaduraE Dejana
Oct 12, 2000·Biochemical and Biophysical Research Communications·H OzakiT Kita
May 17, 2003·Blood·Meghna U NaikUlhas P Naik
Citations
Jan 6, 2007·Circulation Research·Philipp von Hundelshausen, Christian Weber
Nov 25, 2011·Proteomics·Bernice WrightJonathan M Gibbins
Dec 5, 2014·Circulation Research·Ela KarshovskaRory R Koenen
Mar 18, 2016·Molecular Biology of the Cell·David W ScottKeith Burridge
Jan 25, 2012·Blood·Meghna U NaikUlhas P Naik
Aug 14, 2015·Current Opinion in Lipidology·Maiwand AhmadseiNorbert Gerdes
Nov 12, 2015·Mediators of Inflammation·Stephanie DenkMarkus Huber-Lang
Apr 29, 2016·Oncology Reports·Huishan ZhaoWen G Jiang
Dec 15, 2017·Cellular and Molecular Life Sciences : CMLS·Tim SteinbacherKlaus Ebnet
Mar 29, 2018·Cells·Daniel Kummer, Klaus Ebnet
Mar 9, 2019·Journal of Hematology & Oncology·Jiansong HuangJie Jin
Jul 7, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Paul F BradfieldBeat A Imhof
Sep 9, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Offer ErezRoberto Romero
Aug 19, 2017·International Journal of Molecular Sciences·Katalin KoltaiKalman Toth
Feb 13, 2019·Mucosal Immunology·Anny-Claude LuissintCharles A Parkos
Apr 11, 2020·Medical Microbiology and Immunology·Daniel KummerKlaus Ebnet
Jun 28, 2011·Journal of Translational Medicine·Bani M AzariAnna Babinska
Jul 17, 2010·Veterinary Pathology·P A PesaventoJ S Parker
Sep 22, 2017·Physiological Reviews·Klaus Ebnet
Oct 7, 2006·Acta Neuropathologica·Maureen PaddenStephen McQuaid
Nov 25, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Alma ZerneckeChristian Weber
Nov 8, 2007·Blood·Yasuyoshi SuganoAtsushi Miyajima
Dec 13, 2005·Gene·T SobockiE Kornecki
Sep 18, 2021·Molecular and Cellular Biochemistry·Kamila Czubak-ProwizorMaria Swiatkowska