Signaling pathways of the F11 receptor (F11R; a.k.a. JAM-1, JAM-A) in human platelets: F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa

Journal of Receptor and Signal Transduction Research
Malgorzata B SobockaE Kornecki

Abstract

The F11 receptor (F11R) (a.k.a. Junctional Adhesion Molecule, JAM) was first identified in human platelets as a 32/35 kDa protein duplex that serves as receptor for a functional monoclonal antibody that activates platelets. We have sequenced and cloned the F11R and determined that it is a member of the immunoglobulin (Ig) superfamily of cell adhesion molecules. The signaling pathways involved in F11R-induced platelet activation were examined in this investigation. The binding of M.Ab.F11 to the platelet F11R resulted in granule secretion and aggregation. These processes were found to be dependent on the crosslinking of F11R with the Fc gammaRII by M.Ab.F11. This crosslinking induced actin filament assembly with the conversion of discoidal platelets to activated shapes, leading to the formation of platelet aggregates. We demonstrate that platelet secretion and aggregation through the F11R involves actin filament assembly that is dependent on phosphoinositide-3 kinase activation, and inhibitable by wortmannin. Furthermore, such activation results in an increase in the level of free intracellular calcium, phosphorylation of the 32 and 35 kDa forms of the F11R, F11R dimerization coincident with a decrease in monomeric F11R, and ass...Continue Reading

References

Sep 1, 1992·The Journal of Cell Biology·J H Hartwig
Jun 1, 1989·Trends in Pharmacological Sciences·U T Rüegg, G M Burgess
Jan 1, 1987·Advances in Experimental Medicine and Biology·D R SibleyR J Lefkowitz
Mar 13, 1986·Biochemical and Biophysical Research Communications·T TamaokiF Tomita
Oct 15, 1986·Thrombosis Research·A YamaguchiH Yamazaki
Oct 12, 2000·Biochemical and Biophysical Research Communications·H OzakiT Kita

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Citations

Jan 6, 2007·Circulation Research·Philipp von Hundelshausen, Christian Weber
Mar 18, 2016·Molecular Biology of the Cell·David W ScottKeith Burridge
Aug 14, 2015·Current Opinion in Lipidology·Maiwand AhmadseiNorbert Gerdes
Apr 29, 2016·Oncology Reports·Huishan ZhaoWen G Jiang
Dec 15, 2017·Cellular and Molecular Life Sciences : CMLS·Tim SteinbacherKlaus Ebnet
Mar 29, 2018·Cells·Daniel Kummer, Klaus Ebnet
Mar 9, 2019·Journal of Hematology & Oncology·Jiansong HuangJie Jin
Jul 7, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Paul F BradfieldBeat A Imhof
Sep 9, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Offer ErezRoberto Romero
Aug 19, 2017·International Journal of Molecular Sciences·Katalin KoltaiKalman Toth
Apr 11, 2020·Medical Microbiology and Immunology·Daniel KummerKlaus Ebnet
Nov 25, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Alma ZerneckeChristian Weber
Sep 18, 2021·Molecular and Cellular Biochemistry·Kamila Czubak-ProwizorMaria Swiatkowska

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