Signaling thresholds and interclonal competition in preimmune B-cell selection

Immunological Reviews
J G Cyster

Abstract

The need to eliminate autoreactive B cells must be checked against the need for a diverse B-cell repertoire. Protein tyrosine phosphatases SHP1 and CD45 act antagonistically within B cells to set the threshold level of antigen-receptor engagement required for B-cell elimination. The fate of B cells binding weak autoantigens is also regulated by interclonal competition. In the presence of a normal diverse repertoire of competitor B cells, the autoantigen-binding cells are excluded from follicles in spleen and lymph nodes and undergo rapid cell death. In the absence of interclonal competition, the autoreactive cells enter the follicular microenvironment and survive. A model in which B cells compete for access to limiting follicular niches in order to survive is discussed.

References

May 1, 1976·Cellular Immunology·P Nieuwenhuis, W L Ford
Sep 1, 1975·The Journal of Heredity·M C Green, L D Shultz
Jan 1, 1992·International Reviews of Immunology·J F KearneyM Vakil
Jan 1, 1992·International Review of Cytology·G Kraal
Feb 1, 1992·Infection and Immunity·S E RossG H Cassell
Jan 1, 1992·The Journal of Experimental Medicine·M OkamotoT Honjo
Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J PlutzkyR D Rosenberg
Jun 1, 1991·The Journal of Experimental Medicine·H GuI Förster
Feb 1, 1990·Clinical Biochemistry·R A Donald
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·I Förster, K Rajewsky
Jan 1, 1989·Pediatric Radiology·J L StrifeR Martin
Jan 1, 1987·Current Topics in Microbiology and Immunology·R M Perlmutter
Mar 1, 1988·The Journal of Experimental Medicine·D Gray
Mar 1, 1988·The Journal of Experimental Medicine·C J PainterC A Bona
Aug 1, 1972·European Journal of Immunology·J Sprent, J F Miller
Apr 1, 1973·Cellular Immunology·J Sprent, A Basten
Dec 1, 1973·Transplantation·G A Gutman, I L Weissman
Jan 1, 1980·Immunological Reviews·T E MandelJ G Tew
Jan 1, 1981·Immunological Reviews·N R RoseR S Sundick

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Citations

Feb 28, 1998·Immunologic Research·J EriksonJ H Roark
May 29, 1998·Current Opinion in Immunology·I C MacLennan
Oct 23, 1998·The Journal of Experimental Medicine·M C CookA Basten
Oct 18, 2000·The Journal of Experimental Medicine·R M KedlP Marrack
Jul 24, 2007·Blood·Stephen M JacksonJ Donald Capra
Jul 1, 2004·Arthritis Research & Therapy·Sara A Johnson, John C Cambier
Aug 29, 1997·The Journal of Experimental Medicine·Y J Liu
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael P Cancro, John F Kearney
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P M DammersF G Kroese
Feb 14, 2004·Immunological Reviews·Michael P Cancro
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K Reif, J G Cyster
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T J YunE A Clark
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leonard L DragoneArthur Weiss
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A KaserH Tilg
Feb 14, 2004·Immunological Reviews·Emmanuelle GaudinAntonio A Freitas

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