Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus

Cell Stem Cell
Helena MiraFred H Gage

Abstract

Neural stem cells (NSCs) in the adult hippocampus divide infrequently, and the molecules that modulate their quiescence are largely unknown. Here, we show that bone morphogenetic protein (BMP) signaling is active in hippocampal NSCs, downstream of BMPR-IA. BMPs reversibly diminish proliferation of cultured NSCs while maintaining their undifferentiated state. In vivo, acute blockade of BMP signaling in the hippocampus by intracerebral infusion of Noggin first recruits quiescent NSCs into the cycle and increases neurogenesis; subsequently, it leads to decreased stem cell division and depletion of precursors and newborn neurons. Consistently, selective ablation of Bmpr1a in hippocampal NSCs, or inactivation of BMP canonical signaling in conditional Smad4 knockout mice, transiently enhances proliferation but later leads to a reduced number of precursors, thereby limiting neuronal birth. BMPs are therefore required to balance NSC quiescence/proliferation and to prevent loss of the stem cell activity that supports continuous neurogenesis in the mature hippocampus.

References

Mar 11, 1999·Current Opinion in Neurobiology·S Temple, A Alvarez-Buylla
Mar 10, 2000·Science·T ChengD T Scadden
Mar 20, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·V CoskunM B Luskin
May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·K NakashimaT Taga
Jul 9, 2002·Current Opinion in Genetics & Development·David M Panchision, Ronald D G McKay
Nov 19, 2003·The Journal of Comparative Neurology·Golo KronenbergGerd Kempermann
Jan 1, 2004·Genes & Development·Edgar M PeraEddy M De Robertis
Mar 30, 2004·Journal of Neuroscience Research·Alison K Hall, Robert H Miller
Sep 24, 2004·The Journal of Comparative Neurology·Bettina SeriArturo Alvarez-Buylla
Jul 19, 2005·Annual Review of Neuroscience·Guo-li Ming, Hongjun Song
Aug 27, 2005·Oncogene·Alison C Varga, Jeffrey L Wrana
Oct 28, 2005·Nature·Dieter-Chichung LieFred H Gage
Oct 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jovica NinkovicMagdalena Götz
Jan 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dilek ColakMagdalena Götz
Feb 26, 2008·Cell·Chunmei ZhaoFred H Gage
Sep 12, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael A BonaguidiJohn A Kessler
Jun 6, 2009·Cell Stem Cell·Freda D Miller, Andrée Gauthier-Fisher
Jan 30, 2010·Science·Linheng Li, Hans Clevers
Feb 11, 2010·Cell Stem Cell·Justin Voog, D Leanne Jones

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Citations

May 31, 2014·BioMed Research International·Pilar González-GómezHelena Mira
Feb 12, 2014·The Journal of Cell Biology·Gwenvael Le DréauElisa Martí
Mar 25, 2014·Journal of Translational Medicine·Adriano Barreto NogueiraManoel Jacobsen Teixeira
Aug 18, 2012·Cellular and Molecular Life Sciences : CMLS·Giorgia Quadrato, Simone Di Giovanni
Aug 16, 2014·Trends in Cell Biology·Sebastian Jessberger, Fred H Gage
Dec 12, 2012·Cell Stem Cell·Naoki Oshimori, Elaine Fuchs
Mar 21, 2012·Stem Cell Research & Therapy·Roberta Sottocornola, Cristina Lo Celso
Nov 3, 2010·Cell Research·Zhengang YangHongjun Song
Jul 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhengliang GaoJenny Hsieh
Feb 15, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kristy L TownsendYu-Hua Tseng
Nov 10, 2011·Cellular and Molecular Life Sciences : CMLS·Pierre BeukelaersBrigitte Malgrange
Dec 22, 2012·Human Molecular Genetics·Almudena Fuster-MatanzoFélix Hernández
Sep 18, 2012·Nature Neuroscience·Randolph S AshtonDavid V Schaffer
Dec 30, 2014·Stem Cells·Hanadie YousefDavid V Schaffer
Aug 6, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·N HeidariA Ahmadzadeh
Jan 30, 2016·Nature Communications·Rouven DingChristian Berger
May 3, 2012·Protein & Cell·Jun YaoFred H Gage
Mar 20, 2015·Developmental Neurobiology·Julia HolzmannHermann Rohrer
Feb 18, 2016·Stem Cells International·Citlalli Regalado-SantiagoElisa Tamariz
May 12, 2011·Behavioural Brain Research·Ryoichiro KageyamaMasayuki Sakamoto
Jun 28, 2011·Neurochemistry International·Jana VukovicPerry F Bartlett
Jan 21, 2016·Stem Cells International·Yan-Chuang HanXin-Fu Zhou
Oct 31, 2012·Developmental Neurobiology·Johannes ElsasMartin Häusler
May 20, 2011·Developmental Neurobiology·Caghan KizilMichael Brand
Sep 18, 2012·The European Journal of Neuroscience·Mirjam SibbeMichael Frotscher
Apr 14, 2016·Stem Cells International·Lachlan HarrisJulian Ik-Tsen Heng
Apr 28, 2012·Developmental Neurobiology·Andrew ChojnackiSamuel Weiss
Oct 3, 2015·Cell Stem Cell·Allison M BondHongjun Song
Jan 22, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jovica Ninkovic, Magdalena Götz

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