Signaling through the Primary Cilium

Frontiers in Cell and Developmental Biology
Gabrielle WhewayJohn T Hancock

Abstract

The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It wasn't until 2003, with the discovery that proteins responsible for transport along the primary cilium are essential for hedgehog signaling in mice, that the fundamental importance of primary cilia in signal transduction was realized. Little more than a decade later, it is now clear that the vast majority of signaling pathways in vertebrates function through the primary cilium. This has led to the adoption of the term "the cells's antenna" as a description for the primary cilium. Primary cilia are particularly important during development, playing fundamental roles in embryonic patterning and organogenesis, with a suite of inherited developmental disorders known as the "ciliopathies" resulting from mutations in genes encoding cilia proteins. This review summarizes our current understanding of the role of these fascinating organelles in a wide range of signaling pathways.

References

Apr 13, 1999·Neuroscience·M HändelV Höllt
Mar 8, 2000·Mechanisms of Development·D WarburtonW V Cardoso
May 16, 2000·Nature·J B WallingfordR M Harland
Dec 28, 2002·American Journal of Medical Genetics. Part a·Lisa A SchimmentiMaximilian Muenke
Apr 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Fangming LinPeter Igarashi
Nov 7, 2003·Nature·Danwei HuangfuKathryn V Anderson
Aug 24, 2004·Nature Genetics·Russell J FerlandChristopher A Walsh
Aug 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Danwei Huangfu, Kathryn V Anderson
Sep 2, 2005·Nature·Kevin C CorbitJeremy F Reiter
Oct 26, 2005·Current Biology : CB·Linda SchneiderSøren T Christensen
Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jonathan M ShillingfordThomas Weimbs
Aug 5, 2006·Science·Veena Singla, Jeremy F Reiter
Nov 1, 2006·Biochimica Et Biophysica Acta·Chunmin DongGuangyu Wu
Feb 17, 2007·Journal of Neuroscience Research·Nicolas F BerbariKirk Mykytyn
Jun 8, 2007·Development·Jeanette VierkottenUlrich Rüther
Jul 21, 2007·Science·Rajat RohatgiMatthew P Scott
Dec 11, 2007·Nature Genetics·Chonnettia JonesPing Chen
Mar 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Nicolas F BerbariKirk Mykytyn
Jul 8, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jonathan L Tobin, Philip L Beales
Aug 5, 2008·American Journal of Human Genetics·Vincent CantagrelJoseph G Gleeson
May 12, 2009·Nature Genetics·Hemant KhannaNicholas Katsanis
Aug 25, 2009·Development·Peng Huang, Alexander F Schier
Aug 25, 2009·Nature Medicine·Young-Goo HanArturo Alvarez-Buylla
Aug 25, 2009·Nature Medicine·Sunny Y WongJeremy F Reiter
Sep 1, 2009·PloS One·Polloneal Jymmiel R OcbinaKathryn V Anderson
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Seongjin SeoVal C Sheffield
Jan 30, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Linda SchneiderSøren T Christensen

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Citations

Apr 28, 2018·Nature Reviews. Nephrology·Edgar A Otto
Aug 31, 2018·International Journal of Molecular Sciences·Maja SabolSonja Levanat
Nov 23, 2018·Essays in Biochemistry·Jacob T CroftJohanna L Höög
Feb 16, 2019·Thyroid : Official Journal of the American Thyroid Association·José María Fernández-SantosInés Martín-Lacave
Feb 17, 2019·Cells·Helena SoaresJoão Gonçalves
Feb 6, 2019·Biology of the Cell·Madeline Louise Reilly, Alexandre Benmerah
Apr 26, 2019·Journal of Cutaneous Pathology·Nick R LoveJinah Kim
Mar 31, 2019·Biology of Reproduction·Sadman SakibIna Dobrinski
May 30, 2019·International Journal of Molecular Sciences·Sabrina EhnertAndreas K Nussler
Jul 13, 2019·Cells·Vladimir Joukov, Arcangela De Nicolo
Aug 1, 2019·Cells·Chiara Cassioli, Cosima T Baldari
Nov 16, 2019·PLoS Genetics·John SnedekerRolf W Stottmann
Sep 11, 2019·The Journal of Clinical Investigation·Yoan ArribatPascale Bomont
Nov 26, 2019·Translational Science of Rare Diseases·Holly Yu ChenAnand Swaroop
Dec 7, 2019·PLoS Biology·Raj LuxmiBetty A Eipper
Jul 4, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Pablo IruzubietaConcepción Junquera
Sep 29, 2019·Cellular and Molecular Life Sciences : CMLS·Giulia Bertolin, Marc Tramier
May 10, 2020·EMBO Molecular Medicine·Angelisa FrascaNicoletta Landsberger
May 26, 2020·International Ophthalmology·Tianchang TaoGenlin Li
Jun 6, 2020·Journal of Cell Science·Tiffany Yu, Miho Matsuda
Jul 30, 2020·Birth Defects Research·Yu JiChengji J Zhou
Sep 8, 2020·Endocrinology and Metabolism·Yeonjoo Kim, Soo-Hyun Kim
Oct 12, 2018·Therapeutic Advances in Medical Oncology·María Álvarez-Satta, Ander Matheu
Mar 27, 2019·Journal of Molecular Histology·Jimena AlciaturiRossana Sapiro
Mar 8, 2019·Frontiers in Cellular Neuroscience·Matthew R Sarkisian, Susan L Semple-Rowland
Mar 20, 2019·Frontiers in Psychiatry·Michal Pruski, Bing Lang
Jun 15, 2019·Italian Journal of Pediatrics·Elena ManaraMatteo Bertelli
Nov 30, 2019·Frontiers in Genetics·Noriaki SasaiToru Kondo
Jan 30, 2020·International Journal of Molecular Sciences·Antonio Villalobo, Martin W Berchtold
Apr 3, 2020·Microbiology and Molecular Biology Reviews : MMBR·Felice D KellyScott M Landfear
Jul 25, 2020·The Journal of Cell Biology·Jaclyn M Fingerhut, Yukiko M Yamashita
Sep 19, 2018·Development·Lei Wang, Brian D Dynlacht
Mar 28, 2019·Frontiers in Genetics·Gabrielle WhewayUNKNOWN Genomics England Research Consortium
May 28, 2019·Frontiers in Cell and Developmental Biology·Michael G SugiyamaCostin N Antonescu
Nov 11, 2019·GeroScience·Alexander M KulminskiIrina Culminskaya
Jan 22, 2020·Cellular and Molecular Life Sciences : CMLS·Françoise Schoentgen, Slavica Jonic
Sep 6, 2018·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Sophie HinreinerUte Hehr
Jan 4, 2020·Journal of Cell Science·Suzanna L Prosser, Laurence Pelletier
Mar 28, 2020·International Journal of Molecular Sciences·Jeaho LimJa-Eun Kim
Sep 30, 2020·Nature Structural & Molecular Biology·Petra KieselGaia Pigino

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Methods Mentioned

BETA
scanning electron microscopy
transgenic
nuclear translocation
ubiquitination

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