Signaling to transcription networks in the neuronal retrograde injury response.

Science Signaling
Izhak MichaelevskiMike Fainzilber

Abstract

Retrograde signaling from axon to soma activates intrinsic regeneration mechanisms in lesioned peripheral sensory neurons; however, the links between axonal injury signaling and the cell body response are not well understood. Here, we used phosphoproteomics and microarrays to implicate approximately 900 phosphoproteins in retrograde injury signaling in rat sciatic nerve axons in vivo and approximately 4500 transcripts in the in vivo response to injury in the dorsal root ganglia. Computational analyses of these data sets identified approximately 400 redundant axonal signaling networks connected to 39 transcription factors implicated in the sensory neuron response to axonal injury. Experimental perturbation of individual overrepresented signaling hub proteins, including Abl, AKT, p38, and protein kinase C, affected neurite outgrowth in sensory neurons. Paradoxically, however, combined perturbation of Abl together with other hub proteins had a reduced effect relative to perturbation of individual proteins. Our data indicate that nerve injury responses are controlled by multiple regulatory components, and suggest that network redundancies provide robustness to the injury response.

References

Sep 7, 2001·Nature Neuroscience·F L WatsonR A Segal
Apr 30, 2003·Neuron·Clifford J Woolf
Dec 23, 2003·Neuron·Shlomit HanzMike Fainzilber
Jan 6, 2004·Journal of Neurobiology·Eran PerlsonMike Fainzilber
Mar 17, 2004·Current Opinion in Neurobiology·Martin E Schwab
May 22, 2004·European Journal of Biochemistry·Charleen T ChuDonald B DeFranco
Sep 29, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Georgia MandolesiGian Michele Ratto
Oct 12, 2004·International Review of Neurobiology·B M BolstadT P Speed
Feb 3, 2005·Nucleic Acids Research·Yael GartenYitzhak Pilpel
Feb 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jin QiuStephen W N Thompson
Mar 2, 2005·The Journal of Cell Biology·Valeria CavalliLawrence S B Goldstein
Feb 3, 2006·Molecular & Cellular Proteomics : MCP·Jonathan C TrinidadAlma L Burlingame
Feb 17, 2006·Nature Reviews. Molecular Cell Biology·Boris N Kholodenko
May 24, 2006·Progress in Neurobiology·Gennadij Raivich, Axel Behrens
Aug 11, 2006·Journal of Neurochemistry·Shlomit Hanz, Mike Fainzilber
Aug 31, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Feng-Quan Zhou, William D Snider
Oct 19, 2006·Journal of Molecular Biology·Eran PerlsonMike Fainzilber
Nov 23, 2006·BMC Bioinformatics·Alexdander KelEdgar Wingender
Dec 19, 2006·Methods in Molecular Biology·Mouldy Sioud, Marianne Leirdal
Jan 20, 2007·Progress in Neurobiology·Ferdinando RossiLuigi Corvetti
Jan 24, 2007·Nature Reviews. Neuroscience·Frédéric Marmigère, Patrik Ernfors
Jul 6, 2007·The European Journal of Neuroscience·Floor J StamJoost Verhaagen
Jul 27, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rhona SeijffersClifford J Woolf
Aug 28, 2007·Experimental Neurology·Sari S Hannila, Marie T Filbin
Oct 12, 2007·Experimental Neurology·Paul Lu, Mark H Tuszynski
Nov 22, 2007·Trends in Cell Biology·Carlos F Ibáñez
Dec 7, 2007·Molecular & Cellular Proteomics : MCP·Jonathan C TrinidadAlma L Burlingame
Jan 19, 2008·The Journal of Pharmacology and Experimental Therapeutics·Marc K Hellerstein
Jun 10, 2008·Nature Neuroscience·Richard D EmesSeth G N Grant
Jul 29, 2008·Current Opinion in Neurobiology·Namiko Abe, Valeria Cavalli
Sep 10, 2008·Current Opinion in Neurobiology·Katharina E CoskerRosalind A Segal
Oct 15, 2008·SAR and QSAR in Environmental Research·A KelE Wingender
Jan 6, 2009·International Review of Cell and Molecular Biology·Zofia M LasieckaBettina Winckler
Jan 24, 2009·Science·Marc HammarlundMichael Bastiani
Feb 11, 2009·Cell·Ran KafriYitzhak Pilpel
Mar 12, 2009·Analytical Chemistry·Christine Piggee
Apr 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Edmund R HollisMark H Tuszynski

❮ Previous
Next ❯

Citations

Apr 25, 2012·Cell and Tissue Research·Julianne McCallArmin Blesch
May 15, 2012·Cell and Tissue Research·Smriti Patodia, Gennadij Raivich
May 8, 2013·Experimental Eye Research·Kimberly A FernandesRichard T Libby
Jun 27, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark R EmmettCarol L Nilsson
Apr 14, 2012·Nature Reviews. Neuroscience·Hosung JungChristine E Holt
Feb 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher J DonnellyJeffery L Twiss
Apr 26, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amar N KarBarry B Kaplan
Nov 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mike FainzilberMichael R Kreutz
Sep 15, 2014·Trends in Neurosciences·Meifan Chen, Binhai Zheng
Oct 2, 2014·Neuromolecular Medicine·Nitish D FagoeJoost Verhaagen
Mar 14, 2013·ACS Chemical Biology·Hassan Al-AliJohn L Bixby
Jan 10, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paola NixMichael Bastiani
Feb 7, 2013·Plastic and Reconstructive Surgery·Jung-Hsien HsiehSung-Tsang Hsieh
Feb 9, 2012·The Journal of Cell Biology·Inna V Nechipurenko, Heather T Broihier
May 6, 2015·FEBS Letters·Ella Doron-MandelMarco Terenzio
Feb 24, 2016·Neuron·Vijayendran ChandranDaniel H Geschwind
Sep 16, 2015·The European Journal of Neuroscience·Tessa Gordon, Wolfram Tetzlaff
May 5, 2011·Molecular and Cellular Neurosciences·Ona E Bloom, Jennifer R Morgan
Oct 9, 2015·Developmental Neurobiology·Juan Pablo LezanaMiguel Bronfman
Feb 15, 2012·Journal of Neuroscience Research·Kathleen M SalernoKathryn M Albers
Nov 23, 2011·The Journal of Gene Medicine·Ryan R WilliamsMary Bartlett Bunge
Feb 16, 2012·The EMBO Journal·Valentina Di Liberto, Valeria Cavalli
Nov 17, 2010·Hippocampus·Luis M Valor, Angel Barco
Jan 27, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Meike GölzenleuchterAndreas S Beutler
Nov 3, 2010·Traffic·Christopher J DonnellyJeffery L Twiss
Aug 25, 2015·Frontiers in Molecular Neuroscience·Thong C Ma, Dianna E Willis
Aug 25, 2015·Molecular Neurobiology·Fernando M MarMónica M Sousa
Jul 17, 2013·Current Opinion in Neurobiology·Naina KurupYishi Jin
Sep 18, 2012·Experimental Neurology·Richard E Zigmond
Feb 2, 2011·Experimental Neurology·Steffen FranzArmin Blesch
Feb 26, 2011·Current Opinion in Neurobiology·Toh Hean Ch'ng, Kelsey C Martin
Sep 23, 2014·Neuroscience·A DeFrancesco-LisowitzR E Zigmond
Oct 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Zhengxin YingValerie M K Verge
Jul 31, 2012·Neuron·Rotem Ben-Tov PerryMike Fainzilber
Apr 15, 2014·Current Opinion in Neurobiology·Yi LuZhigang He
Apr 20, 2011·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Gennadij Raivich
Nov 12, 2013·Cell·Yongcheol ChoValeria Cavalli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.